Comparison of LROC and traditional ROC studies for lesion-detection task

Si Chen, Lana Volokh, Chi Liu, Benjamin M.W. Tsui

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

The goal of this study is to evaluate lesion detectability in In-Ill ProstaScint® SPECT with different image reconstruction methods using receiver operating characteristic (ROC) techniques of traditional signal position known exactly (SPKE) settings and two other different settings. We generated 3D NCAT phantoms with different body sizes, organ uptake ratios, lesion sizes and lesion contrasts to simulate variations found in a patient population. Monte Carlo methods were then used to generate projection data. The projections were reconstructed using the OS-EM algorithm with different compensations including attenuation compensation (AC), AC and scatter compensation (SC) and AC, SC and collimator-detector response compensation (CDR). We used the channelized Hotelling observer (CHO) for all the 3 settings of ROC studies. The area under ROC curves (AUC) was used as the figure of merit to optimize the updates number and postfilter cut-off frequency of OS-EM with different compensations and then compare the optimized methods. The results show that all 3 different settings of ROC study give consistent results for comparing optimized OS-EM with different compensations. ROC setting 2, which involves localization uncertainty and nonlinear combination of body size variations have better statistical power than the SPKE setting (setting 1). The AVC of CHO in ROC setting 2 and 3 are significantly lower than that of setting 1 which may predict better the human observers' performances in clinical trials.[1]

Original languageEnglish (US)
Title of host publication2006 IEEE Nuclear Science Symposium - Conference Record
PublisherInstitute of Electrical and Electronics Engineers Inc.
Pages2072-2075
Number of pages4
ISBN (Print)1424405610, 9781424405619
DOIs
StatePublished - Jan 1 2006
Event2006 IEEE Nuclear Science Symposium, Medical Imaging Conference and 15th International Workshop on Room-Temperature Semiconductor X- and Gamma-Ray Detectors, Special Focus Workshops, NSS/MIC/RTSD - San Diego, CA, United States
Duration: Oct 29 2006Nov 4 2006

Publication series

NameIEEE Nuclear Science Symposium Conference Record
Volume4
ISSN (Print)1095-7863

Other

Other2006 IEEE Nuclear Science Symposium, Medical Imaging Conference and 15th International Workshop on Room-Temperature Semiconductor X- and Gamma-Ray Detectors, Special Focus Workshops, NSS/MIC/RTSD
CountryUnited States
CitySan Diego, CA
Period10/29/0611/4/06

ASJC Scopus subject areas

  • Radiation
  • Nuclear and High Energy Physics
  • Radiology Nuclear Medicine and imaging

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  • Cite this

    Chen, S., Volokh, L., Liu, C., & Tsui, B. M. W. (2006). Comparison of LROC and traditional ROC studies for lesion-detection task. In 2006 IEEE Nuclear Science Symposium - Conference Record (pp. 2072-2075). [4179435] (IEEE Nuclear Science Symposium Conference Record; Vol. 4). Institute of Electrical and Electronics Engineers Inc.. https://doi.org/10.1109/NSSMIC.2006.354321