Comparison of intermittent ethambutol with rifampicin-based regimens in HIV-infected adults with PTB, Kampala

Alphonse Okwera; J. L. Johnson; H. Luzze; P. Nsubuga; H. Kayanja; D. L. Cohn; P. Nunn; J. J. Ellner; C. C. Whalen; R. D. Mugerwa

Comparison of intermittent ethambutol with rifampicin-based regimens in HIV-infected adults with PTB, Kampala

Alphonse Okwera, J. L. Johnson, H. Luzze, P. Nsubuga, H. Kayanja, D. L. Cohn, P. Nunn, J. J. Ellner, C. C. Whalen, R. D. Mugerwa

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17 Scopus citations

Abstract

BACKGROUND: The human immunodeficiency virus (HIV) is a key factor responsible for the high rates of tuberculosis (TB) in sub-Saharan Africa. Treatment of TB with rifampicin (R, RMP) containing short-course regimens is highly effective in HIV-infected adults. We conducted a study to compare the efficacy and safety of intermittent ethambutol (E, EMB) with two RMP-containing regimens to treat pulmonary TB in HIV-infected patients. SETTING: National Tuberculosis Treatment Centre, Mulago Hospital, Kampala, Uganda. DESIGN: This was a prospective cohort compared to two non-randomised control groups. The study group and the two control arms were treated with 2 months of isoniazid (H), RMP, pyrazinamide (Z) and EMB followed by 6 E₃H₃ for the study group and 4HR or 6HR for controls. RESULTS: Between April 1993 and March 2000, 136 patients were enrolled in the 2EHRZ/E3H3 arm, 147 in the 2EHRZ/4HR arm and 266 in the 2EHRZ/6HR arm. The relapse rate was 18.2 per 100 person-years observation (PYO) for the study regimen compared to 9.7/100 PYO (P = 0.0063) and 4.8/100 PYO (P = 0.0001) in patients treated with 2 EHRZ/4HR or 2EHRZ/6HR, respectively. CONCLUSION: The 2EHRZ/6E₃H₃ regimen is safe and effective but has a significant risk of relapse.

Original language	English (US)
Pages (from-to)	39-44
Number of pages	6
Journal	International Journal of Tuberculosis and Lung Disease
Volume	10
Issue number	1
State	Published - Jan 2006
Externally published	Yes

Keywords

Ethambutol
HIV/AIDS
Rifampicin
Treatment
Tuberculosis

ASJC Scopus subject areas

Pulmonary and Respiratory Medicine

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@article{cd7bbb5854b34c45a0968cad523bddc7,

title = "Comparison of intermittent ethambutol with rifampicin-based regimens in HIV-infected adults with PTB, Kampala",

abstract = "BACKGROUND: The human immunodeficiency virus (HIV) is a key factor responsible for the high rates of tuberculosis (TB) in sub-Saharan Africa. Treatment of TB with rifampicin (R, RMP) containing short-course regimens is highly effective in HIV-infected adults. We conducted a study to compare the efficacy and safety of intermittent ethambutol (E, EMB) with two RMP-containing regimens to treat pulmonary TB in HIV-infected patients. SETTING: National Tuberculosis Treatment Centre, Mulago Hospital, Kampala, Uganda. DESIGN: This was a prospective cohort compared to two non-randomised control groups. The study group and the two control arms were treated with 2 months of isoniazid (H), RMP, pyrazinamide (Z) and EMB followed by 6 E3H3 for the study group and 4HR or 6HR for controls. RESULTS: Between April 1993 and March 2000, 136 patients were enrolled in the 2EHRZ/E3H3 arm, 147 in the 2EHRZ/4HR arm and 266 in the 2EHRZ/6HR arm. The relapse rate was 18.2 per 100 person-years observation (PYO) for the study regimen compared to 9.7/100 PYO (P = 0.0063) and 4.8/100 PYO (P = 0.0001) in patients treated with 2 EHRZ/4HR or 2EHRZ/6HR, respectively. CONCLUSION: The 2EHRZ/6E3H3 regimen is safe and effective but has a significant risk of relapse.",

keywords = "Ethambutol, HIV/AIDS, Rifampicin, Treatment, Tuberculosis",

author = "Alphonse Okwera and Johnson, {J. L.} and H. Luzze and P. Nsubuga and H. Kayanja and Cohn, {D. L.} and P. Nunn and Ellner, {J. J.} and Whalen, {C. C.} and Mugerwa, {R. D.}",

year = "2006",

month = jan,

language = "English (US)",

volume = "10",

pages = "39--44",

journal = "International Journal of Tuberculosis and Lung Disease",

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publisher = "International Union against Tubercul. and Lung Dis.",

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T1 - Comparison of intermittent ethambutol with rifampicin-based regimens in HIV-infected adults with PTB, Kampala

AU - Okwera, Alphonse

AU - Johnson, J. L.

AU - Luzze, H.

AU - Nsubuga, P.

AU - Kayanja, H.

AU - Cohn, D. L.

AU - Nunn, P.

AU - Ellner, J. J.

AU - Whalen, C. C.

AU - Mugerwa, R. D.

PY - 2006/1

Y1 - 2006/1

N2 - BACKGROUND: The human immunodeficiency virus (HIV) is a key factor responsible for the high rates of tuberculosis (TB) in sub-Saharan Africa. Treatment of TB with rifampicin (R, RMP) containing short-course regimens is highly effective in HIV-infected adults. We conducted a study to compare the efficacy and safety of intermittent ethambutol (E, EMB) with two RMP-containing regimens to treat pulmonary TB in HIV-infected patients. SETTING: National Tuberculosis Treatment Centre, Mulago Hospital, Kampala, Uganda. DESIGN: This was a prospective cohort compared to two non-randomised control groups. The study group and the two control arms were treated with 2 months of isoniazid (H), RMP, pyrazinamide (Z) and EMB followed by 6 E3H3 for the study group and 4HR or 6HR for controls. RESULTS: Between April 1993 and March 2000, 136 patients were enrolled in the 2EHRZ/E3H3 arm, 147 in the 2EHRZ/4HR arm and 266 in the 2EHRZ/6HR arm. The relapse rate was 18.2 per 100 person-years observation (PYO) for the study regimen compared to 9.7/100 PYO (P = 0.0063) and 4.8/100 PYO (P = 0.0001) in patients treated with 2 EHRZ/4HR or 2EHRZ/6HR, respectively. CONCLUSION: The 2EHRZ/6E3H3 regimen is safe and effective but has a significant risk of relapse.

AB - BACKGROUND: The human immunodeficiency virus (HIV) is a key factor responsible for the high rates of tuberculosis (TB) in sub-Saharan Africa. Treatment of TB with rifampicin (R, RMP) containing short-course regimens is highly effective in HIV-infected adults. We conducted a study to compare the efficacy and safety of intermittent ethambutol (E, EMB) with two RMP-containing regimens to treat pulmonary TB in HIV-infected patients. SETTING: National Tuberculosis Treatment Centre, Mulago Hospital, Kampala, Uganda. DESIGN: This was a prospective cohort compared to two non-randomised control groups. The study group and the two control arms were treated with 2 months of isoniazid (H), RMP, pyrazinamide (Z) and EMB followed by 6 E3H3 for the study group and 4HR or 6HR for controls. RESULTS: Between April 1993 and March 2000, 136 patients were enrolled in the 2EHRZ/E3H3 arm, 147 in the 2EHRZ/4HR arm and 266 in the 2EHRZ/6HR arm. The relapse rate was 18.2 per 100 person-years observation (PYO) for the study regimen compared to 9.7/100 PYO (P = 0.0063) and 4.8/100 PYO (P = 0.0001) in patients treated with 2 EHRZ/4HR or 2EHRZ/6HR, respectively. CONCLUSION: The 2EHRZ/6E3H3 regimen is safe and effective but has a significant risk of relapse.

KW - Ethambutol

KW - HIV/AIDS

KW - Rifampicin

KW - Treatment

KW - Tuberculosis

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M3 - Article

C2 - 16466035

AN - SCOPUS:33144471064

SN - 1027-3719

VL - 10

SP - 39

EP - 44

JO - International Journal of Tuberculosis and Lung Disease

JF - International Journal of Tuberculosis and Lung Disease

IS - 1

ER -

Comparison of intermittent ethambutol with rifampicin-based regimens in HIV-infected adults with PTB, Kampala

Abstract

Keywords

ASJC Scopus subject areas

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