Comparison of intermediate-term outcomes of coronary artery bypass grafting versus drug-eluting stents for patients ≥75 years of age

Edward L. Hannan, Ye Zhong, Peter B. Berger, Gary Walford, Jeptha P. Curtis, Chuntao Wu, Ferdinand J. Venditti, Robert S.D. Higgins, Craig R. Smith, Stephen J. Lahey, Spencer B. King

Research output: Contribution to journalArticlepeer-review

Abstract

Several randomized controlled trials and observational studies have compared outcomes of percutaneous coronary interventions (PCIs) with drug-eluting stents (DESs) and coronary artery bypass grafting (CABG), but they have not thoroughly investigated the relative difference in outcomes for patients aged ≥75 years. In this study, a total of 3,864 patients receiving DES and CABG (1,932 CABG-DES pairs) with multivessel coronary disease were propensity matched using multiple patient risk factors and were compared with respect to 3 outcomes (mortality, stroke/myocardial infarction [MI]/mortality, and repeat revascularization) at 2.5 years with a mean follow-up of 18 months. The mortality rates (DES/CABG hazard ratio 1.06, 95% confidence interval 0.87 to 1.30) and the stroke/MI/mortality rates (DES/CABG hazard ratio 1.15, 95% confidence interval 0.97 to 1.38) for the 2 procedures were not significantly different. Repeat revascularization rates were significantly higher for patients who received DESs. In conclusion, older patients experienced similar mortality and stroke/MI/mortality rates for CABG and PCI with DES, although repeat revascularization rates were higher for patients undergoing PCI with DES.

Original languageEnglish (US)
Pages (from-to)803-808
Number of pages6
JournalAmerican Journal of Cardiology
Volume113
Issue number5
DOIs
StatePublished - Mar 1 2014

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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