Comparison of intensive versus moderate chemotherapy of lymphocytic lymphomas. A progress report

Ediz Ezdinli, Stuart Pocock, C. W. Berard, C. William Aungst, Murray Silverstein, John Horton, John Bennett, Richard Bakemeier, Leo Stolbach, Charles Perlia, S. Fred Brunk, Raymond E. Lenhard, D. J. Klaassen, Paul Richter, Paul Carbone

Research output: Contribution to journalArticlepeer-review

Abstract

In an Eastern Cooperative Oncology Group trial, Cytoxan‐prednisone (CP) Induction was compared to BCNU‐prednisone (BP) in 273 patients with lymphocytic lymphoma. Response rates were comparable, with 21% achieving complete response and 40%, partial response. Patients with a nodular pattern responded better. Maintenance phase comparing cyclic intensive therapy (BCVP) with intermittent chlorambucil revealed the superiority of BCVP as demonstrated by improvement of the quality of response and somewhat longer remissions. The value of the Rappaport classification in the evaluation of lymphoma chemotherapy results is discussed. It is suggested that NHL be separated into “favorable” and “unfavorable” groups, based on the presence or absence of nodularity and treatment schedules devised accordingly.

Original languageEnglish (US)
Pages (from-to)1060-1068
Number of pages9
JournalCancer
Volume38
Issue number3
DOIs
StatePublished - Sep 1976

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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