Comparison of indices of regional lung function from 4-D X-ray CT

Jacobian vs. strain of deformation

Mohammadreza Negahdar, Neal Dunlap, Albert Zacarias, Ali Civelek, Shiao Y. Woo, Amir A. Amini

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

In the literature, a widely adopted approach for assessing the regional lung function in patients undergoing radiation therapy for lung cancer from 4-D X-ray CT data is the Jacobian of deformation. The Jacobian which describes regional lung volume changes however lacks consideration of directional length changes during respiration. Previously, we proposed the use of strain for measurement of regional deformation in the Lung [1]. In this paper, we perform physiologic validation of lung strain and compare the results with those from the Jacobian measure. Lung deformation fields were computed through application of a recently proposed 3-D optical flow technique (MOFID) [2] to 4-D X-ray CT data sets collected in seven subjects diagnosed with non-small cell primary lung cancer. In addition to 4-D CT data, both SPECT ventilation (VSPECT), and SPECT perfusion (QSPECT data were acquired in all subjects. For each case, voxel-wise statistical correlation of the Jacobian as well as principal strains of deformation (CT-derived pulmonary function images) with both ventilation and perfusion SPECT was performed. The results indicate that the maximum principal strain has a higher correlation with both SPECT ventilation and SPECT perfusion than other indices including the Jacobian.

Original languageEnglish (US)
Title of host publicationProceedings - International Symposium on Biomedical Imaging
Pages648-651
Number of pages4
DOIs
StatePublished - 2013
Externally publishedYes
Event2013 IEEE 10th International Symposium on Biomedical Imaging: From Nano to Macro, ISBI 2013 - San Francisco, CA, United States
Duration: Apr 7 2013Apr 11 2013

Other

Other2013 IEEE 10th International Symposium on Biomedical Imaging: From Nano to Macro, ISBI 2013
CountryUnited States
CitySan Francisco, CA
Period4/7/134/11/13

Fingerprint

X Ray Computed Tomography
Single-Photon Emission-Computed Tomography
Ventilation
X rays
Lung
Perfusion
Optical flows
Radiotherapy
Non-Small Cell Lung Carcinoma
Lung Neoplasms
Respiration

Keywords

  • 4-D X-ray CT
  • Deformable Image Registration
  • Radiation Therapy
  • Regional Lung Function
  • SPECT

ASJC Scopus subject areas

  • Biomedical Engineering
  • Radiology Nuclear Medicine and imaging

Cite this

Negahdar, M., Dunlap, N., Zacarias, A., Civelek, A., Woo, S. Y., & Amini, A. A. (2013). Comparison of indices of regional lung function from 4-D X-ray CT: Jacobian vs. strain of deformation. In Proceedings - International Symposium on Biomedical Imaging (pp. 648-651). [6556558] https://doi.org/10.1109/ISBI.2013.6556558

Comparison of indices of regional lung function from 4-D X-ray CT : Jacobian vs. strain of deformation. / Negahdar, Mohammadreza; Dunlap, Neal; Zacarias, Albert; Civelek, Ali; Woo, Shiao Y.; Amini, Amir A.

Proceedings - International Symposium on Biomedical Imaging. 2013. p. 648-651 6556558.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Negahdar, M, Dunlap, N, Zacarias, A, Civelek, A, Woo, SY & Amini, AA 2013, Comparison of indices of regional lung function from 4-D X-ray CT: Jacobian vs. strain of deformation. in Proceedings - International Symposium on Biomedical Imaging., 6556558, pp. 648-651, 2013 IEEE 10th International Symposium on Biomedical Imaging: From Nano to Macro, ISBI 2013, San Francisco, CA, United States, 4/7/13. https://doi.org/10.1109/ISBI.2013.6556558
Negahdar M, Dunlap N, Zacarias A, Civelek A, Woo SY, Amini AA. Comparison of indices of regional lung function from 4-D X-ray CT: Jacobian vs. strain of deformation. In Proceedings - International Symposium on Biomedical Imaging. 2013. p. 648-651. 6556558 https://doi.org/10.1109/ISBI.2013.6556558
Negahdar, Mohammadreza ; Dunlap, Neal ; Zacarias, Albert ; Civelek, Ali ; Woo, Shiao Y. ; Amini, Amir A. / Comparison of indices of regional lung function from 4-D X-ray CT : Jacobian vs. strain of deformation. Proceedings - International Symposium on Biomedical Imaging. 2013. pp. 648-651
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