Comparison of immune responses in patients infected with Vibrio cholerae O139 and O1

Firdausi Qadri, Christine Wennerås, M. John Albert, Jaber Hossain, Kaiissar Mannoor, Yasmin Ara Begum, Golam Mohi, Mohammad Abdus Salam, R. Bradley Sack, Ann Mari Svennerholm

Research output: Contribution to journalArticle

Abstract

Vibrio cholerae O139 has recently emerged as the second etiologic agent of cholera in Asia. A study was carried out to evaluate the induction of specific immune responses to the organism in V. cholerae O139-infected patients. The immune responses to V. cholerae O139 Bengal were studied in patients by measuring antibody-secreting cells (ASC), as well as vibriocidal and antitoxic antibodies in the circulation. These responses were compared with those in patients with V. cholerae O1 disease. Strong immunoglobulin A (IgA) and IgM ASC responses were seen against the homologous lipopolysaccharide or serogroup of V. cholerae. The magnitude and isotype of the responses were similar in O139- and O1-infected patients. Vibriocidal antibody responses were seen against bacteria of the homologous but not heterologous serogroup, and these responses reflect the lack of cross-protection between the infections caused by the two serogroups. The two groups of patients showed comparable cholera toxin-specific ASC responses, with the IgG isotype dominating over the IgA isotype, as well as comparable antitoxic immune responses in plasma. These results suggest that despite having a polysaccharide capsule, V. cholerae O139 induces systemic and intestine-derived ASC responses in peripheral blood comparable to those seen in patients with V. cholerae O1 disease.

Original languageEnglish (US)
Pages (from-to)3571-3576
Number of pages6
JournalInfection and immunity
Volume65
Issue number9
DOIs
StatePublished - Sep 1997

ASJC Scopus subject areas

  • Parasitology
  • Microbiology
  • Immunology
  • Infectious Diseases

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    Qadri, F., Wennerås, C., Albert, M. J., Hossain, J., Mannoor, K., Begum, Y. A., Mohi, G., Salam, M. A., Sack, R. B., & Svennerholm, A. M. (1997). Comparison of immune responses in patients infected with Vibrio cholerae O139 and O1. Infection and immunity, 65(9), 3571-3576. https://doi.org/10.1128/iai.65.9.3571-3576.1997