Abstract
Objectives: The aim of the study was to compare clinical/imaging findings and outcome in patients with idiopathic (isolated aortitis, IA) and with giant cell arteritis (GCA)-related aortitis. Methods: Patients from 11 French internal medicine departments were retrospectively included. Aortitis was defined by aortic wall thickening >. 2 mm and/or an aortic aneurysm on CT-scan, associated to inflammatory syndrome. Patients with GCA had at least 3 ACR criteria. Aortic events (aneurysm, dissection, aortic surgeries) were reported, and free of aortic events-survival were compared. Results: Among 191 patients with non-infectious aortitis, 73 with GCA and 44 with IA were included. Patients with IA were younger (65 vs 70 years, p = 0.003) and comprised more past/current smokers (43 vs 15%, p = 0.0007). Aortic aneurisms were more frequent (38% vs 20%, p = 0.03), and aortic wall thickening was more pronounced in IA. During follow-up (median = 34 months), subsequent development of aortic aneurysm was significantly lower in GCA when compared to IA (p = 0.009). GCA patients required significantly less aortic surgery during follow-up than IA patients (p = 0.02). Mean age, sex ratio, inflammatory parameters, and free of aortic aneurism survival were equivalent in patients with IA ≥ 60 years when compared to patients with GCA-related aortitis. Conclusions: IA is more severe than aortitis related to GCA, with higher proportions of aortic aneurism at diagnosis and during follow-up. IA is a heterogeneous disease and its prognosis is worse in younger patients
| Original language | English (US) |
|---|---|
| Pages (from-to) | 571-576 |
| Number of pages | 6 |
| Journal | Autoimmunity Reviews |
| Volume | 15 |
| Issue number | 6 |
| DOIs | |
| State | Published - Jun 1 2016 |
| Externally published | Yes |
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Keywords
- Aortic aneurysm
- Aortitis
- Giant cell arteritis
- Idiopathic aortitis
- Isolated aortitis
ASJC Scopus subject areas
- Immunology
- Immunology and Allergy
Cite this
Comparison of idiopathic (isolated) aortitis and giant cell arteritis-related aortitis. A French retrospective multicenter study of 117 patients. / Espitia, Olivier; Samson, Maxime; Le Gallou, Thomas; Connault, Jérôme; Landron, Cedric; Lavigne, Christian; Belizna, Cristina; Magnant, Julie; de Moreuil, Claire; Roblot, Pascal; Maillot, François; Diot, Elisabeth; Jégo, Patrick; Durant, Cécile; Masseau, A.; Brisseau, Jean Marie; Pottier, Pierre; Espitia-Thibault, Alexandra; Santos, Anabele Dos; Perrin, François; Artifoni, Mathieu; Néel, Antoine; Graveleau, Julie; Moreau, Philippe; Maisonneuve, Hervé; Fau, Georges; Serfaty, Jean Michel; Hamidou, Mohamed; Agard, Christian.
In: Autoimmunity Reviews, Vol. 15, No. 6, 01.06.2016, p. 571-576.Research output: Contribution to journal › Review article
}
TY - JOUR
T1 - Comparison of idiopathic (isolated) aortitis and giant cell arteritis-related aortitis. A French retrospective multicenter study of 117 patients
AU - Espitia, Olivier
AU - Samson, Maxime
AU - Le Gallou, Thomas
AU - Connault, Jérôme
AU - Landron, Cedric
AU - Lavigne, Christian
AU - Belizna, Cristina
AU - Magnant, Julie
AU - de Moreuil, Claire
AU - Roblot, Pascal
AU - Maillot, François
AU - Diot, Elisabeth
AU - Jégo, Patrick
AU - Durant, Cécile
AU - Masseau, A.
AU - Brisseau, Jean Marie
AU - Pottier, Pierre
AU - Espitia-Thibault, Alexandra
AU - Santos, Anabele Dos
AU - Perrin, François
AU - Artifoni, Mathieu
AU - Néel, Antoine
AU - Graveleau, Julie
AU - Moreau, Philippe
AU - Maisonneuve, Hervé
AU - Fau, Georges
AU - Serfaty, Jean Michel
AU - Hamidou, Mohamed
AU - Agard, Christian
PY - 2016/6/1
Y1 - 2016/6/1
N2 - Objectives: The aim of the study was to compare clinical/imaging findings and outcome in patients with idiopathic (isolated aortitis, IA) and with giant cell arteritis (GCA)-related aortitis. Methods: Patients from 11 French internal medicine departments were retrospectively included. Aortitis was defined by aortic wall thickening >. 2 mm and/or an aortic aneurysm on CT-scan, associated to inflammatory syndrome. Patients with GCA had at least 3 ACR criteria. Aortic events (aneurysm, dissection, aortic surgeries) were reported, and free of aortic events-survival were compared. Results: Among 191 patients with non-infectious aortitis, 73 with GCA and 44 with IA were included. Patients with IA were younger (65 vs 70 years, p = 0.003) and comprised more past/current smokers (43 vs 15%, p = 0.0007). Aortic aneurisms were more frequent (38% vs 20%, p = 0.03), and aortic wall thickening was more pronounced in IA. During follow-up (median = 34 months), subsequent development of aortic aneurysm was significantly lower in GCA when compared to IA (p = 0.009). GCA patients required significantly less aortic surgery during follow-up than IA patients (p = 0.02). Mean age, sex ratio, inflammatory parameters, and free of aortic aneurism survival were equivalent in patients with IA ≥ 60 years when compared to patients with GCA-related aortitis. Conclusions: IA is more severe than aortitis related to GCA, with higher proportions of aortic aneurism at diagnosis and during follow-up. IA is a heterogeneous disease and its prognosis is worse in younger patients
AB - Objectives: The aim of the study was to compare clinical/imaging findings and outcome in patients with idiopathic (isolated aortitis, IA) and with giant cell arteritis (GCA)-related aortitis. Methods: Patients from 11 French internal medicine departments were retrospectively included. Aortitis was defined by aortic wall thickening >. 2 mm and/or an aortic aneurysm on CT-scan, associated to inflammatory syndrome. Patients with GCA had at least 3 ACR criteria. Aortic events (aneurysm, dissection, aortic surgeries) were reported, and free of aortic events-survival were compared. Results: Among 191 patients with non-infectious aortitis, 73 with GCA and 44 with IA were included. Patients with IA were younger (65 vs 70 years, p = 0.003) and comprised more past/current smokers (43 vs 15%, p = 0.0007). Aortic aneurisms were more frequent (38% vs 20%, p = 0.03), and aortic wall thickening was more pronounced in IA. During follow-up (median = 34 months), subsequent development of aortic aneurysm was significantly lower in GCA when compared to IA (p = 0.009). GCA patients required significantly less aortic surgery during follow-up than IA patients (p = 0.02). Mean age, sex ratio, inflammatory parameters, and free of aortic aneurism survival were equivalent in patients with IA ≥ 60 years when compared to patients with GCA-related aortitis. Conclusions: IA is more severe than aortitis related to GCA, with higher proportions of aortic aneurism at diagnosis and during follow-up. IA is a heterogeneous disease and its prognosis is worse in younger patients
KW - Aortic aneurysm
KW - Aortitis
KW - Giant cell arteritis
KW - Idiopathic aortitis
KW - Isolated aortitis
UR - http://www.scopus.com/inward/record.url?scp=84961149864&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84961149864&partnerID=8YFLogxK
U2 - 10.1016/j.autrev.2016.02.016
DO - 10.1016/j.autrev.2016.02.016
M3 - Review article
VL - 15
SP - 571
EP - 576
JO - Autoimmunity Reviews
JF - Autoimmunity Reviews
SN - 1568-9972
IS - 6
ER -