Comparison of idiopathic (isolated) aortitis and giant cell arteritis-related aortitis. A French retrospective multicenter study of 117 patients

Olivier Espitia, Maxime Samson, Thomas Le Gallou, Jérôme Connault, Cedric Landron, Christian Lavigne, Cristina Belizna, Julie Magnant, Claire de Moreuil, Pascal Roblot, François Maillot, Elisabeth Diot, Patrick Jégo, Cécile Durant, A. Masseau, Jean Marie Brisseau, Pierre Pottier, Alexandra Espitia-Thibault, Anabele Dos Santos, François Perrin & 9 others Mathieu Artifoni, Antoine Néel, Julie Graveleau, Philippe Moreau, Hervé Maisonneuve, Georges Fau, Jean Michel Serfaty, Mohamed Hamidou, Christian Agard

Research output: Contribution to journalReview article

Abstract

Objectives: The aim of the study was to compare clinical/imaging findings and outcome in patients with idiopathic (isolated aortitis, IA) and with giant cell arteritis (GCA)-related aortitis. Methods: Patients from 11 French internal medicine departments were retrospectively included. Aortitis was defined by aortic wall thickening >. 2 mm and/or an aortic aneurysm on CT-scan, associated to inflammatory syndrome. Patients with GCA had at least 3 ACR criteria. Aortic events (aneurysm, dissection, aortic surgeries) were reported, and free of aortic events-survival were compared. Results: Among 191 patients with non-infectious aortitis, 73 with GCA and 44 with IA were included. Patients with IA were younger (65 vs 70 years, p = 0.003) and comprised more past/current smokers (43 vs 15%, p = 0.0007). Aortic aneurisms were more frequent (38% vs 20%, p = 0.03), and aortic wall thickening was more pronounced in IA. During follow-up (median = 34 months), subsequent development of aortic aneurysm was significantly lower in GCA when compared to IA (p = 0.009). GCA patients required significantly less aortic surgery during follow-up than IA patients (p = 0.02). Mean age, sex ratio, inflammatory parameters, and free of aortic aneurism survival were equivalent in patients with IA ≥ 60 years when compared to patients with GCA-related aortitis. Conclusions: IA is more severe than aortitis related to GCA, with higher proportions of aortic aneurism at diagnosis and during follow-up. IA is a heterogeneous disease and its prognosis is worse in younger patients

Original languageEnglish (US)
Pages (from-to)571-576
Number of pages6
JournalAutoimmunity Reviews
Volume15
Issue number6
DOIs
StatePublished - Jun 1 2016
Externally publishedYes

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Aortitis
Giant Cell Arteritis
Multicenter Studies
Retrospective Studies
Aortic Aneurysm
Sex Ratio
Internal Medicine

Keywords

  • Aortic aneurysm
  • Aortitis
  • Giant cell arteritis
  • Idiopathic aortitis
  • Isolated aortitis

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy

Cite this

Comparison of idiopathic (isolated) aortitis and giant cell arteritis-related aortitis. A French retrospective multicenter study of 117 patients. / Espitia, Olivier; Samson, Maxime; Le Gallou, Thomas; Connault, Jérôme; Landron, Cedric; Lavigne, Christian; Belizna, Cristina; Magnant, Julie; de Moreuil, Claire; Roblot, Pascal; Maillot, François; Diot, Elisabeth; Jégo, Patrick; Durant, Cécile; Masseau, A.; Brisseau, Jean Marie; Pottier, Pierre; Espitia-Thibault, Alexandra; Santos, Anabele Dos; Perrin, François; Artifoni, Mathieu; Néel, Antoine; Graveleau, Julie; Moreau, Philippe; Maisonneuve, Hervé; Fau, Georges; Serfaty, Jean Michel; Hamidou, Mohamed; Agard, Christian.

In: Autoimmunity Reviews, Vol. 15, No. 6, 01.06.2016, p. 571-576.

Research output: Contribution to journalReview article

Espitia, O, Samson, M, Le Gallou, T, Connault, J, Landron, C, Lavigne, C, Belizna, C, Magnant, J, de Moreuil, C, Roblot, P, Maillot, F, Diot, E, Jégo, P, Durant, C, Masseau, A, Brisseau, JM, Pottier, P, Espitia-Thibault, A, Santos, AD, Perrin, F, Artifoni, M, Néel, A, Graveleau, J, Moreau, P, Maisonneuve, H, Fau, G, Serfaty, JM, Hamidou, M & Agard, C 2016, 'Comparison of idiopathic (isolated) aortitis and giant cell arteritis-related aortitis. A French retrospective multicenter study of 117 patients', Autoimmunity Reviews, vol. 15, no. 6, pp. 571-576. https://doi.org/10.1016/j.autrev.2016.02.016
Espitia, Olivier ; Samson, Maxime ; Le Gallou, Thomas ; Connault, Jérôme ; Landron, Cedric ; Lavigne, Christian ; Belizna, Cristina ; Magnant, Julie ; de Moreuil, Claire ; Roblot, Pascal ; Maillot, François ; Diot, Elisabeth ; Jégo, Patrick ; Durant, Cécile ; Masseau, A. ; Brisseau, Jean Marie ; Pottier, Pierre ; Espitia-Thibault, Alexandra ; Santos, Anabele Dos ; Perrin, François ; Artifoni, Mathieu ; Néel, Antoine ; Graveleau, Julie ; Moreau, Philippe ; Maisonneuve, Hervé ; Fau, Georges ; Serfaty, Jean Michel ; Hamidou, Mohamed ; Agard, Christian. / Comparison of idiopathic (isolated) aortitis and giant cell arteritis-related aortitis. A French retrospective multicenter study of 117 patients. In: Autoimmunity Reviews. 2016 ; Vol. 15, No. 6. pp. 571-576.
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abstract = "Objectives: The aim of the study was to compare clinical/imaging findings and outcome in patients with idiopathic (isolated aortitis, IA) and with giant cell arteritis (GCA)-related aortitis. Methods: Patients from 11 French internal medicine departments were retrospectively included. Aortitis was defined by aortic wall thickening >. 2 mm and/or an aortic aneurysm on CT-scan, associated to inflammatory syndrome. Patients with GCA had at least 3 ACR criteria. Aortic events (aneurysm, dissection, aortic surgeries) were reported, and free of aortic events-survival were compared. Results: Among 191 patients with non-infectious aortitis, 73 with GCA and 44 with IA were included. Patients with IA were younger (65 vs 70 years, p = 0.003) and comprised more past/current smokers (43 vs 15{\%}, p = 0.0007). Aortic aneurisms were more frequent (38{\%} vs 20{\%}, p = 0.03), and aortic wall thickening was more pronounced in IA. During follow-up (median = 34 months), subsequent development of aortic aneurysm was significantly lower in GCA when compared to IA (p = 0.009). GCA patients required significantly less aortic surgery during follow-up than IA patients (p = 0.02). Mean age, sex ratio, inflammatory parameters, and free of aortic aneurism survival were equivalent in patients with IA ≥ 60 years when compared to patients with GCA-related aortitis. Conclusions: IA is more severe than aortitis related to GCA, with higher proportions of aortic aneurism at diagnosis and during follow-up. IA is a heterogeneous disease and its prognosis is worse in younger patients",
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T1 - Comparison of idiopathic (isolated) aortitis and giant cell arteritis-related aortitis. A French retrospective multicenter study of 117 patients

AU - Espitia, Olivier

AU - Samson, Maxime

AU - Le Gallou, Thomas

AU - Connault, Jérôme

AU - Landron, Cedric

AU - Lavigne, Christian

AU - Belizna, Cristina

AU - Magnant, Julie

AU - de Moreuil, Claire

AU - Roblot, Pascal

AU - Maillot, François

AU - Diot, Elisabeth

AU - Jégo, Patrick

AU - Durant, Cécile

AU - Masseau, A.

AU - Brisseau, Jean Marie

AU - Pottier, Pierre

AU - Espitia-Thibault, Alexandra

AU - Santos, Anabele Dos

AU - Perrin, François

AU - Artifoni, Mathieu

AU - Néel, Antoine

AU - Graveleau, Julie

AU - Moreau, Philippe

AU - Maisonneuve, Hervé

AU - Fau, Georges

AU - Serfaty, Jean Michel

AU - Hamidou, Mohamed

AU - Agard, Christian

PY - 2016/6/1

Y1 - 2016/6/1

N2 - Objectives: The aim of the study was to compare clinical/imaging findings and outcome in patients with idiopathic (isolated aortitis, IA) and with giant cell arteritis (GCA)-related aortitis. Methods: Patients from 11 French internal medicine departments were retrospectively included. Aortitis was defined by aortic wall thickening >. 2 mm and/or an aortic aneurysm on CT-scan, associated to inflammatory syndrome. Patients with GCA had at least 3 ACR criteria. Aortic events (aneurysm, dissection, aortic surgeries) were reported, and free of aortic events-survival were compared. Results: Among 191 patients with non-infectious aortitis, 73 with GCA and 44 with IA were included. Patients with IA were younger (65 vs 70 years, p = 0.003) and comprised more past/current smokers (43 vs 15%, p = 0.0007). Aortic aneurisms were more frequent (38% vs 20%, p = 0.03), and aortic wall thickening was more pronounced in IA. During follow-up (median = 34 months), subsequent development of aortic aneurysm was significantly lower in GCA when compared to IA (p = 0.009). GCA patients required significantly less aortic surgery during follow-up than IA patients (p = 0.02). Mean age, sex ratio, inflammatory parameters, and free of aortic aneurism survival were equivalent in patients with IA ≥ 60 years when compared to patients with GCA-related aortitis. Conclusions: IA is more severe than aortitis related to GCA, with higher proportions of aortic aneurism at diagnosis and during follow-up. IA is a heterogeneous disease and its prognosis is worse in younger patients

AB - Objectives: The aim of the study was to compare clinical/imaging findings and outcome in patients with idiopathic (isolated aortitis, IA) and with giant cell arteritis (GCA)-related aortitis. Methods: Patients from 11 French internal medicine departments were retrospectively included. Aortitis was defined by aortic wall thickening >. 2 mm and/or an aortic aneurysm on CT-scan, associated to inflammatory syndrome. Patients with GCA had at least 3 ACR criteria. Aortic events (aneurysm, dissection, aortic surgeries) were reported, and free of aortic events-survival were compared. Results: Among 191 patients with non-infectious aortitis, 73 with GCA and 44 with IA were included. Patients with IA were younger (65 vs 70 years, p = 0.003) and comprised more past/current smokers (43 vs 15%, p = 0.0007). Aortic aneurisms were more frequent (38% vs 20%, p = 0.03), and aortic wall thickening was more pronounced in IA. During follow-up (median = 34 months), subsequent development of aortic aneurysm was significantly lower in GCA when compared to IA (p = 0.009). GCA patients required significantly less aortic surgery during follow-up than IA patients (p = 0.02). Mean age, sex ratio, inflammatory parameters, and free of aortic aneurism survival were equivalent in patients with IA ≥ 60 years when compared to patients with GCA-related aortitis. Conclusions: IA is more severe than aortitis related to GCA, with higher proportions of aortic aneurism at diagnosis and during follow-up. IA is a heterogeneous disease and its prognosis is worse in younger patients

KW - Aortic aneurysm

KW - Aortitis

KW - Giant cell arteritis

KW - Idiopathic aortitis

KW - Isolated aortitis

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JO - Autoimmunity Reviews

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