Comparison of histologic and immunologic heterogeneity of non-Hodgkin's lymphomas

M. J. Borowitz, B. P. Croker, R. S. Metzgar

Research output: Contribution to journalArticlepeer-review

20 Scopus citations


The lymphocyte surface marker phenotype in 11 selected cases of non-Hodgkin's lymphomas was determined with anti-immunoglobulin and mouse monoclonal antibodies against human lymphocyte antigens. A complement-mediated cell cytotoxicity assay on suspensions of the tumor cells was compared with an indirect immunoperoxidase technique on frozen tissue sections. Both methods gave good results in tumors with a uniform cell population, but the frozen section technique was superior in heterogeneous tumors. The six B-cell neoplasms were heterogeneous with respect to expression of surface immunoglobulin and Ia antigens. The five T-cell tumors were morphologically heterogeneous and also highly variable in their expression of different T-cell specific antigens.

Original languageEnglish (US)
Pages (from-to)97-106
Number of pages10
JournalAmerican Journal of Pathology
Issue number2
StatePublished - Jan 1 1981
Externally publishedYes

ASJC Scopus subject areas

  • Pathology and Forensic Medicine


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