Abstract
The lymphocyte surface marker phenotype in 11 selected cases of non-Hodgkin's lymphomas was determined with anti-immunoglobulin and mouse monoclonal antibodies against human lymphocyte antigens. A complement-mediated cell cytotoxicity assay on suspensions of the tumor cells was compared with an indirect immunoperoxidase technique on frozen tissue sections. Both methods gave good results in tumors with a uniform cell population, but the frozen section technique was superior in heterogeneous tumors. The six B-cell neoplasms were heterogeneous with respect to expression of surface immunoglobulin and Ia antigens. The five T-cell tumors were morphologically heterogeneous and also highly variable in their expression of different T-cell specific antigens.
Original language | English (US) |
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Pages (from-to) | 97-106 |
Number of pages | 10 |
Journal | American Journal of Pathology |
Volume | 105 |
Issue number | 2 |
State | Published - Jan 1 1981 |
Externally published | Yes |
ASJC Scopus subject areas
- Pathology and Forensic Medicine