Comparison of GnRH antagonists and flareup GnRH agonists in donor oocyte cycles

Alex Y. Wei, Katherine A. Mijal, Mindy S. Christianson, Calisa M. Schouweiler, Steven R. Lindheim

Research output: Contribution to journalArticlepeer-review


OBJECTIVE: To compare the flareup GnRH-antagonist (GnRH-ant) and GnRH-agonist (GnRH-a) protocols in oocyte donation cycles, using the donor as her own control. STUDY DESIGN: A retrospective review at a university-based practice of 22 oocyte donors who underwent 29 cycles using recombinant follicle-stimulating hormone (FSH) and GnRH-ant and 28 cycles using flareup GnRH-a with recombinant FSH. Recipients (n = 57) were synchronized with estrogen and progesterone supplementation. RESULTS: The total number of recombinant FSH used and days of stimulation were similar between the groups; however, cycle days 5 estradiol (341 ± 40 vs. 473 ± 62 pg/mL), peak serum estradiol (1,721 ± 170 vs. 3,625 ± 295 pg/mL) and the number of retrieved MII oocytes (17 ± 1.5 vs. 29 ± 7) were significantly higher in the flareup GnRH-a group. Similar fertilization rates, embryos transferred, clinical pregnancy rate/embryo transfer (44%, 11/25; vs. 55%, 15/27), delivered pregnancy rate/embryo transfer (32%, 8/25; vs. 52%, 14/27) and implantation rates (31 ± 6% vs. 28 ± 5%) were seen in each group. CONCLUSION: Both the flareup GnRH-a and GnRH-ant are shortened, simplified and efficacious protocols in oocyte donation cycles.

Original languageEnglish (US)
Pages (from-to)147-150
Number of pages4
JournalJournal of Reproductive Medicine for the Obstetrician and Gynecologist
Issue number3
StatePublished - Mar 1 2008
Externally publishedYes


  • Embryo transfer
  • Gonadotropin-releasing hormone
  • Hormone antagonists
  • In vitro fertilization
  • Oocyte donation

ASJC Scopus subject areas

  • Reproductive Medicine
  • Obstetrics and Gynecology


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