Comparison of genome degradation in Paratyphi A and Typhi, human-restricted serovars of Salmonella enterica that cause typhoid

Michael McClelland, Kenneth E. Sanderson, Sandra W. Clifton, Phil Latreille, Steffen Porwollik, Aniko Sabo, Rekha Meyer, Tamberlyn Bieri, Phil Ozersky, Michael McLellan, C. Richard Harkins, Chunyan Wang, Christine Nguyen, Amy Berghoff, Glendoria Elliott, Sara Kohlberg, Cindy Strong, Feiyu Du, Jason Carter, Colin KremizkiDan Layman, Shawn Leonard, Hui Sun, Lucinda Fulton, William Nash, Tracie Miner, Patrick Minx, Kim Delehaunty, Catrina Fronick, Vincent Magrini, Michael Nhan, Wesley Warren, Liliana Florea, John Spieth, Richard K. Wilson

Research output: Contribution to journalArticlepeer-review

286 Scopus citations


Salmonella enterica serovars often have a broad host range, and some cause both gastrointestinal and systemic disease. But the serovars Paratyphi A and Typhi are restricted to humans and cause only systemic disease. It has been estimated that Typhi arose in the last few thousand years. The sequence and microarray analysis of the Paratyphi A genome indicates that it is similar to the Typhi genome but suggests that it has a more recent evolutionary origin. Both genomes have independently accumulated many pseudogenes among their ∼4,400 protein coding sequences: 173 in Paratyphi A and ∼210 in Typhi. The recent convergence of these two similar genomes on a similar phenotype is subtly reflected in their genotypes: only 30 genes are degraded in both serovars. Nevertheless, these 30 genes include three known to be important in gastroenteritis, which does not occur in these serovars, and four for Salmonella-translocated effectors, which are normally secreted into host cells to subvert host functions. Loss of function also occurs by mutation in different genes in the same pathway (e.g., in chemotaxis and in the production of fimbriae).

Original languageEnglish (US)
Pages (from-to)1268-1274
Number of pages7
JournalNature genetics
Issue number12
StatePublished - Dec 2004
Externally publishedYes

ASJC Scopus subject areas

  • Genetics


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