Comparison of Gait Parameters for Predicting Cognitive Decline: The Mayo Clinic Study of Aging

Rodolfo Savica, Alexandra M V Wennberg, Clinton Hagen, Kelly Edwards, Rosebud O. Roberts, John H. Hollman, David S. Knopman, Bradley F. Boeve, Mary M. Machulda, Ronald C. Petersen, Michelle M. Mielke

Research output: Contribution to journalArticle

Abstract

Background: Previous studies reported that slower gait speed might predict cognitive impairment and dementing illnesses, supporting the role of gait speed as a possible subclinical marker of cognitive impairment. However, the predictive value of other gait parameters for cognitive decline is unclear. Objective: To investigate and compare the association with, and prediction of, specific gait parameters for cognition in a population-based sample. Methods: The analysis included 3,426 cognitively normal participants enrolled in the Mayo Clinic Study of Aging. At baseline and every 15 months (mean follow-up = 1.93 years), participants had a study coordinator evaluation, neurological examination, and a neuropsychological assessment using nine tests that covered four domains. Gait parameters were assessed with the GAITRite® instrument. General linear mixed effects models were used to compute the annualized rate of change in cognitive domain z-scores, controlling for age, sex, education, depression, comorbidities, body mass index, APOE ϵ4 allele, and visit number, and excluding individuals with a history of stroke, alcoholism, Parkinson's disease, subdural hematoma, and normal pressure hydrocephalus. Results: Spatial (stride length), temporal (ambulatory time, gait speed, step count, cadence, double support time), and spatiotemporal (cadence) gait parameters, and greater intraindividual variability in stride length, swing time, and stance time were associated with a significant decline in global cognition and in specific domains including memory, executive function, visuospatial, and language. Conclusions: Spatial, temporal, and spatiotemporal measures of gait and greater variability of gait parameters were associated with and predictive of both global- and domain-specific cognitive decline.

Original languageEnglish (US)
Pages (from-to)559-567
Number of pages9
JournalJournal of Alzheimer's Disease
Volume55
Issue number2
DOIs
StatePublished - 2017
Externally publishedYes

Fingerprint

Gait
Cognition
Normal Pressure Hydrocephalus
Subdural Hematoma
Sex Education
Executive Function
Neurologic Examination
Alcoholism
Parkinson Disease
Comorbidity
Body Mass Index
Alleles
Depression

Keywords

  • Cognition
  • epidemiology
  • gait variability
  • GAITRite® instrument

ASJC Scopus subject areas

  • Clinical Psychology
  • Geriatrics and Gerontology
  • Psychiatry and Mental health

Cite this

Savica, R., Wennberg, A. M. V., Hagen, C., Edwards, K., Roberts, R. O., Hollman, J. H., ... Mielke, M. M. (2017). Comparison of Gait Parameters for Predicting Cognitive Decline: The Mayo Clinic Study of Aging. Journal of Alzheimer's Disease, 55(2), 559-567. DOI: 10.3233/JAD-160697

Comparison of Gait Parameters for Predicting Cognitive Decline : The Mayo Clinic Study of Aging. / Savica, Rodolfo; Wennberg, Alexandra M V; Hagen, Clinton; Edwards, Kelly; Roberts, Rosebud O.; Hollman, John H.; Knopman, David S.; Boeve, Bradley F.; Machulda, Mary M.; Petersen, Ronald C.; Mielke, Michelle M.

In: Journal of Alzheimer's Disease, Vol. 55, No. 2, 2017, p. 559-567.

Research output: Contribution to journalArticle

Savica, R, Wennberg, AMV, Hagen, C, Edwards, K, Roberts, RO, Hollman, JH, Knopman, DS, Boeve, BF, Machulda, MM, Petersen, RC & Mielke, MM 2017, 'Comparison of Gait Parameters for Predicting Cognitive Decline: The Mayo Clinic Study of Aging' Journal of Alzheimer's Disease, vol 55, no. 2, pp. 559-567. DOI: 10.3233/JAD-160697
Savica R, Wennberg AMV, Hagen C, Edwards K, Roberts RO, Hollman JH et al. Comparison of Gait Parameters for Predicting Cognitive Decline: The Mayo Clinic Study of Aging. Journal of Alzheimer's Disease. 2017;55(2):559-567. Available from, DOI: 10.3233/JAD-160697

Savica, Rodolfo; Wennberg, Alexandra M V; Hagen, Clinton; Edwards, Kelly; Roberts, Rosebud O.; Hollman, John H.; Knopman, David S.; Boeve, Bradley F.; Machulda, Mary M.; Petersen, Ronald C.; Mielke, Michelle M. / Comparison of Gait Parameters for Predicting Cognitive Decline : The Mayo Clinic Study of Aging.

In: Journal of Alzheimer's Disease, Vol. 55, No. 2, 2017, p. 559-567.

Research output: Contribution to journalArticle

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