Comparison of Functional Status, Electrocardiographic, and Echocardiographic Parameters to Mortality in Endomyocardial-Biopsy Proven Cardiac Amyloidosis

Bethany A. Austin, Brendan Duffy, Carmela Tan, E. Rene Rodriguez, Randall C. Starling, Milind Y. Desai

Research output: Contribution to journalArticle

Abstract

Cardiac amyloidosis (CA) is generally associated with a poor prognosis and significantly increased mortality. We sought to identify predictors of longer-term survival in patients with endomyocardial biopsy (EMB)-documented CA. Forty-five consecutive patients with EMB-documented CA were studied from January 1998 to December 2003. Age, gender, New York Heart Association class, medications, presence of light-chain amyloid, and electrocardiographic voltage were recorded. Baseline left ventricular (LV) ejection fraction, deceleration time, diastolic function, LV mass, ventricular septal thickness, and myocardial performance index ([isovolumic contraction time + isovolumic relaxation time]/ejection time) were recorded. Mean age was 66 ± 10 years with 34 men (76%). New York Heart Association class >II was noted in 26 patients (58%) and low voltage on electrocardiogram (S wave [lead V1] + R wave [lead V5] ≤15) in 12 (27%). Mean LV ejection fraction, ventricular septal thickness, and LV mass were 46 ± 13%, 1.7 ± 0.42 cm, and 303 ± 114 g, respectively. Deceleration time ≤150 ms was found in 19 (42%) and myocardial performance index >0.6 in 15 (33%). At a median follow-up of 1.7 years, there were 25 deaths (56%). On univariate Kaplan-Meier analysis, New York Heart Association class >II, deceleration time

Original languageEnglish (US)
Pages (from-to)1429-1433
Number of pages5
JournalThe American Journal of Cardiology
Volume103
Issue number10
DOIs
StatePublished - May 15 2009
Externally publishedYes

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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