Comparison of FDG-PET with MIBI-SPECT in the detection of breast cancer and axillary lymph node metastasis

Kenji Yutani, Eiichi Shiba, Hideo Kusuoka, Mitsuaki Tatsumi, Toshiisa Uehara, Tetsuya Taguchi, Shin Ichiro Takai, Tsunehiko Nishimura

Research output: Contribution to journalArticle

Abstract

Purpose: The purpose of this work was to compare [18F]2-deoxy-2-fluoro-D-glucose (FDG) PET and 99mTc-methoxyisobutylisonitrile (MIBI) SPECT in the detection of breast cancer and axillary lymph node metastasis in the same patients. Method: FDG-PET and MIBI-SPECT were performed within 3 days for 40 women (age range 25-86 years old) with suspected breast cancer, in whom biopsies and/or mastectomies were performed. Both images were visually assessed, and the count ratio between tumor and normal tissue (T/N ratio) was calculated. Results: Thirty-eight patients had breast cancer, and the remaining two had benign breast lesions. The sensitivities of FDG-PET and MIBI-SPECT were 78.9 and 76.3% for breast cancer and 50.0 and 37.5% for axillary lymph node metastasis, respectively. The T/N ratio of breast cancer was significantly higher in FDG-PET (6.01 ± 3.08 mean ± SD) than that in MIBI-SPECT (3.48 ± 1.21) (p = 0.01). Nonmalignant diffuse uptake of FDG in the breasts and the accumulation of MIBI in heart and liver occasionally obscured tumor uptake. Conclusion: These results indicate that MIBI-SPECT is comparable with FDG-PET in detecting breast cancer. Neither FDG-PET nor MIBI-SPECT is sufficiently sensitive to rule out axillary lymph node metastasis.

Original languageEnglish (US)
Pages (from-to)274-280
Number of pages7
JournalJournal of computer assisted tomography
Volume24
Issue number2
DOIs
StatePublished - 2000

Keywords

  • Breasts, neoplasms
  • Positron emission computed tomography
  • Single photon emission computed tomography
  • Tc-methoxyisobutylisonitrile
  • [F]2-Deoxy-2-fluoro-D-glucose

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

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  • Cite this

    Yutani, K., Shiba, E., Kusuoka, H., Tatsumi, M., Uehara, T., Taguchi, T., Takai, S. I., & Nishimura, T. (2000). Comparison of FDG-PET with MIBI-SPECT in the detection of breast cancer and axillary lymph node metastasis. Journal of computer assisted tomography, 24(2), 274-280. https://doi.org/10.1097/00004728-200003000-00017