TY - JOUR
T1 - Comparison of FDG-PET with MIBI-SPECT in the detection of breast cancer and axillary lymph node metastasis
AU - Yutani, Kenji
AU - Shiba, Eiichi
AU - Kusuoka, Hideo
AU - Tatsumi, Mitsuaki
AU - Uehara, Toshiisa
AU - Taguchi, Tetsuya
AU - Takai, Shin Ichiro
AU - Nishimura, Tsunehiko
N1 - Copyright:
Copyright 2007 Elsevier B.V., All rights reserved.
PY - 2000
Y1 - 2000
N2 - Purpose: The purpose of this work was to compare [18F]2-deoxy-2-fluoro-D-glucose (FDG) PET and 99mTc-methoxyisobutylisonitrile (MIBI) SPECT in the detection of breast cancer and axillary lymph node metastasis in the same patients. Method: FDG-PET and MIBI-SPECT were performed within 3 days for 40 women (age range 25-86 years old) with suspected breast cancer, in whom biopsies and/or mastectomies were performed. Both images were visually assessed, and the count ratio between tumor and normal tissue (T/N ratio) was calculated. Results: Thirty-eight patients had breast cancer, and the remaining two had benign breast lesions. The sensitivities of FDG-PET and MIBI-SPECT were 78.9 and 76.3% for breast cancer and 50.0 and 37.5% for axillary lymph node metastasis, respectively. The T/N ratio of breast cancer was significantly higher in FDG-PET (6.01 ± 3.08 mean ± SD) than that in MIBI-SPECT (3.48 ± 1.21) (p = 0.01). Nonmalignant diffuse uptake of FDG in the breasts and the accumulation of MIBI in heart and liver occasionally obscured tumor uptake. Conclusion: These results indicate that MIBI-SPECT is comparable with FDG-PET in detecting breast cancer. Neither FDG-PET nor MIBI-SPECT is sufficiently sensitive to rule out axillary lymph node metastasis.
AB - Purpose: The purpose of this work was to compare [18F]2-deoxy-2-fluoro-D-glucose (FDG) PET and 99mTc-methoxyisobutylisonitrile (MIBI) SPECT in the detection of breast cancer and axillary lymph node metastasis in the same patients. Method: FDG-PET and MIBI-SPECT were performed within 3 days for 40 women (age range 25-86 years old) with suspected breast cancer, in whom biopsies and/or mastectomies were performed. Both images were visually assessed, and the count ratio between tumor and normal tissue (T/N ratio) was calculated. Results: Thirty-eight patients had breast cancer, and the remaining two had benign breast lesions. The sensitivities of FDG-PET and MIBI-SPECT were 78.9 and 76.3% for breast cancer and 50.0 and 37.5% for axillary lymph node metastasis, respectively. The T/N ratio of breast cancer was significantly higher in FDG-PET (6.01 ± 3.08 mean ± SD) than that in MIBI-SPECT (3.48 ± 1.21) (p = 0.01). Nonmalignant diffuse uptake of FDG in the breasts and the accumulation of MIBI in heart and liver occasionally obscured tumor uptake. Conclusion: These results indicate that MIBI-SPECT is comparable with FDG-PET in detecting breast cancer. Neither FDG-PET nor MIBI-SPECT is sufficiently sensitive to rule out axillary lymph node metastasis.
KW - Breasts, neoplasms
KW - Positron emission computed tomography
KW - Single photon emission computed tomography
KW - Tc-methoxyisobutylisonitrile
KW - [F]2-Deoxy-2-fluoro-D-glucose
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U2 - 10.1097/00004728-200003000-00017
DO - 10.1097/00004728-200003000-00017
M3 - Article
C2 - 10752892
AN - SCOPUS:0034466373
SN - 0363-8715
VL - 24
SP - 274
EP - 280
JO - Journal of computer assisted tomography
JF - Journal of computer assisted tomography
IS - 2
ER -