Abstract
Electroporation may be a mechanism for injury to the cardiac cell membrane during electrical defibrillation, if excessive levels of shock are applied. A cell-attached patch-clamp study of single rat ventricular myocytes was conducted to determine whether the voltage thresholds for electroporation differ for two commonly used waveform shapes with widely different tilts: 5 ms rectangular (0% tilt) and 5 ms truncated exponential (67% tilt). When threshold was measured as leading edge voltage, the exponential pulses had, on average, a significantly higher threshold and shorter latency delay for electroporation compared with the rectangular pulses. Therefore, high-tilt exponential pulses may produce less injury via electroporation compared with rectangular pulses.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 251-252 |
| Number of pages | 2 |
| Journal | Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings |
| Volume | 17 |
| Issue number | 1 |
| State | Published - Dec 1 1995 |
| Event | Proceedings of the 1995 IEEE Engineering in Medicine and Biology 17th Annual Conference and 21st Canadian Medical and Biological Engineering Conference. Part 2 (of 2) - Montreal, Can Duration: Sep 20 1995 → Sep 23 1995 |
ASJC Scopus subject areas
- Signal Processing
- Biomedical Engineering
- Computer Vision and Pattern Recognition
- Health Informatics