Comparison of electroporation thresholds of cardiac cell membranes by rectangular and exponential pulses

Leslie Tung, Rory J. O'Neill

Research output: Contribution to journalConference articlepeer-review

Abstract

Electroporation may be a mechanism for injury to the cardiac cell membrane during electrical defibrillation, if excessive levels of shock are applied. A cell-attached patch-clamp study of single rat ventricular myocytes was conducted to determine whether the voltage thresholds for electroporation differ for two commonly used waveform shapes with widely different tilts: 5 ms rectangular (0% tilt) and 5 ms truncated exponential (67% tilt). When threshold was measured as leading edge voltage, the exponential pulses had, on average, a significantly higher threshold and shorter latency delay for electroporation compared with the rectangular pulses. Therefore, high-tilt exponential pulses may produce less injury via electroporation compared with rectangular pulses.

Original languageEnglish (US)
Pages (from-to)251-252
Number of pages2
JournalAnnual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings
Volume17
Issue number1
StatePublished - Dec 1 1995
EventProceedings of the 1995 IEEE Engineering in Medicine and Biology 17th Annual Conference and 21st Canadian Medical and Biological Engineering Conference. Part 2 (of 2) - Montreal, Can
Duration: Sep 20 1995Sep 23 1995

ASJC Scopus subject areas

  • Signal Processing
  • Biomedical Engineering
  • Computer Vision and Pattern Recognition
  • Health Informatics

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