Comparison of diagnostic accuracy of biomarkers with pooled assessments

Aiyi Liu, Enrique F. Schisterman

Research output: Contribution to journalArticle

Abstract

New biomarkers are frequently being developed in laboratory settings for the early diagnosis of diseases. However, the assay can be so expensive to assess in some cases that the evaluation of a large number of assays becomes unfeasible. Under this setting pooling biospecimens becomes an appealing alternative. In this paper, we present the methodology to allow for general pooling strategies and different data structures, which include balanced and unbalanced pooling cases. An estimate of the area under the ROC curve of a single biomarker with its asymptotic mean and variance is provided. Furthermore, we develop a test statistic for comparing the areas under the ROC curves of two biomarkers. The methods are illustrated with data from a study evaluating biomarkers for coronary heart disease.

Original languageEnglish (US)
Pages (from-to)631-644
Number of pages14
JournalBiometrical Journal
Volume45
Issue number5
DOIs
StatePublished - 2003
Externally publishedYes

Fingerprint

Diagnostic Accuracy
Biomarkers
Pooling
Receiver Operating Characteristic Curve
Coronary Heart Disease
Test Statistic
Data Structures
Diagnostics
Methodology
Alternatives
Evaluation
Estimate
Receiver operating characteristic curve

Keywords

  • Pooled analysis
  • Receiver operating characteristics curves
  • Sensitivity
  • Specificity

ASJC Scopus subject areas

  • Statistics and Probability

Cite this

Comparison of diagnostic accuracy of biomarkers with pooled assessments. / Liu, Aiyi; Schisterman, Enrique F.

In: Biometrical Journal, Vol. 45, No. 5, 2003, p. 631-644.

Research output: Contribution to journalArticle

Liu, Aiyi ; Schisterman, Enrique F. / Comparison of diagnostic accuracy of biomarkers with pooled assessments. In: Biometrical Journal. 2003 ; Vol. 45, No. 5. pp. 631-644.
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