Comparison of day 0 and day 14 dosimetry for permanent prostate implants using stranded seeds

Patrick McLaughlin, Vrinda Narayana, Charlie Pan, Sally Berri, Sara Troyer, Joseph Herman, Vicki Evans, Peter Roberson

Research output: Contribution to journalArticle

Abstract

Purpose: To determine, using MRI-based dosimetry (Day 0 and Day 14), whether clinically significant changes in the dose to the prostate and critical adjacent structures occur between Day 0 and 14, and to determine to what degree any changes in dosimetry are due to swelling or its resolution. Methods and Materials: A total of 28 patients with a permanent prostate implant using 125I rapid strands were evaluated at Days 0 and 14 by CT/MRI fusion. The minimal dose received by 90% of the target volume (prostate D90), percentage of volume receiving 100% of prescribed minimal peripheral dose (prostate V100), external sphincter D90, and 4-cm 3 rectal volume dose were calculated. An acceptable prostate D 90 was defined as D90 >90% of prescription dose. Prostate volume changes were calculated and correlated with any dosimetry change. A paradoxic dosimetric result was defined as an improvement in D 90, despite increased swelling; a decrease in D90, despite decreased swelling; or a large change in D90 (>30 Gy) in the absence of swelling. Results: The D90 changed in 27 of 28 patients between Days 0 and 14. No relationship was found between a change in prostate volume and the change in D90 (R2 = 0.01). A paradoxic dosimetric result was noted in 11 of 28 patients. The rectal dose increased in 23 of 28 patients, with a >30-Gy change in 6. The external sphincter D 90 increased in 19 of 28, with a >50-Gy increase in 6. Conclusion: The dose to the prostate changed between Days 0 and 14 in most patients, resulting in a change in clinical status (acceptable or unacceptable) in 12 of 28 patients. Profound increases in normal tissue doses may make dose and toxicity correlations using Day 0 dosimetry difficult. No relationship was found between the prostate volume change and D90 change, and, in 11 patients, a paradoxic dosimetric result was noted. A differential z-axis shift of stranded seeds vs. prostate had a greater impact on final dosimetry and dose to critical adjacent tissues than did prostate swelling. These findings challenge the model that swelling is the principal cause of dosimetric changes after implantation. Stranded seeds may have contributed to this outcome. On the basis of these findings, a change in technique to avoid placement of stranded seeds inferior to the prostate apex has been adopted. These results may not apply to implants using single seeds within the prostate.

Original languageEnglish (US)
Pages (from-to)144-150
Number of pages7
JournalInternational Journal of Radiation Oncology, Biology, Physics
Volume64
Issue number1
DOIs
StatePublished - Jan 1 2006
Externally publishedYes

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dosimeters
seeds
Prostate
Seeds
dosage
swelling
toxicity
strands
implantation
apexes
fusion
Prescriptions
causes
shift

Keywords

  • Postimplant dosimetry
  • Prostate brachytherapy
  • Prostate swelling

ASJC Scopus subject areas

  • Oncology
  • Radiology Nuclear Medicine and imaging
  • Radiation

Cite this

Comparison of day 0 and day 14 dosimetry for permanent prostate implants using stranded seeds. / McLaughlin, Patrick; Narayana, Vrinda; Pan, Charlie; Berri, Sally; Troyer, Sara; Herman, Joseph; Evans, Vicki; Roberson, Peter.

In: International Journal of Radiation Oncology, Biology, Physics, Vol. 64, No. 1, 01.01.2006, p. 144-150.

Research output: Contribution to journalArticle

McLaughlin, P, Narayana, V, Pan, C, Berri, S, Troyer, S, Herman, J, Evans, V & Roberson, P 2006, 'Comparison of day 0 and day 14 dosimetry for permanent prostate implants using stranded seeds', International Journal of Radiation Oncology, Biology, Physics, vol. 64, no. 1, pp. 144-150. https://doi.org/10.1016/j.ijrobp.2005.06.044
McLaughlin, Patrick ; Narayana, Vrinda ; Pan, Charlie ; Berri, Sally ; Troyer, Sara ; Herman, Joseph ; Evans, Vicki ; Roberson, Peter. / Comparison of day 0 and day 14 dosimetry for permanent prostate implants using stranded seeds. In: International Journal of Radiation Oncology, Biology, Physics. 2006 ; Vol. 64, No. 1. pp. 144-150.
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abstract = "Purpose: To determine, using MRI-based dosimetry (Day 0 and Day 14), whether clinically significant changes in the dose to the prostate and critical adjacent structures occur between Day 0 and 14, and to determine to what degree any changes in dosimetry are due to swelling or its resolution. Methods and Materials: A total of 28 patients with a permanent prostate implant using 125I rapid strands were evaluated at Days 0 and 14 by CT/MRI fusion. The minimal dose received by 90{\%} of the target volume (prostate D90), percentage of volume receiving 100{\%} of prescribed minimal peripheral dose (prostate V100), external sphincter D90, and 4-cm 3 rectal volume dose were calculated. An acceptable prostate D 90 was defined as D90 >90{\%} of prescription dose. Prostate volume changes were calculated and correlated with any dosimetry change. A paradoxic dosimetric result was defined as an improvement in D 90, despite increased swelling; a decrease in D90, despite decreased swelling; or a large change in D90 (>30 Gy) in the absence of swelling. Results: The D90 changed in 27 of 28 patients between Days 0 and 14. No relationship was found between a change in prostate volume and the change in D90 (R2 = 0.01). A paradoxic dosimetric result was noted in 11 of 28 patients. The rectal dose increased in 23 of 28 patients, with a >30-Gy change in 6. The external sphincter D 90 increased in 19 of 28, with a >50-Gy increase in 6. Conclusion: The dose to the prostate changed between Days 0 and 14 in most patients, resulting in a change in clinical status (acceptable or unacceptable) in 12 of 28 patients. Profound increases in normal tissue doses may make dose and toxicity correlations using Day 0 dosimetry difficult. No relationship was found between the prostate volume change and D90 change, and, in 11 patients, a paradoxic dosimetric result was noted. A differential z-axis shift of stranded seeds vs. prostate had a greater impact on final dosimetry and dose to critical adjacent tissues than did prostate swelling. These findings challenge the model that swelling is the principal cause of dosimetric changes after implantation. Stranded seeds may have contributed to this outcome. On the basis of these findings, a change in technique to avoid placement of stranded seeds inferior to the prostate apex has been adopted. These results may not apply to implants using single seeds within the prostate.",
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AU - Evans, Vicki

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