Comparison of cytokine expression profile during Wallerian degeneration of myelinated and unmyelinated peripheral axons

Therapoj Cheepudomwit, Emre Güzelsu, Chunhua Zhou, John W. Griffin, Ahmet Höke

Research output: Contribution to journalArticle

Abstract

Changes in cytokine and chemokine expression during Wallerian degeneration have been studied using nerve transection models, which result in denervation of both myelinating and non-myelinating Schwann cells. Cytokine and chemokine response of non-myelinating Remak Schwann cells to loss of their axons is unknown. In this study, we compared the expression profile of various cytokines and chemokines in distal nerves after capsaicin-induced degeneration of unmyelinated axons to Wallerian degeneration induced by nerve transection. Upregulation of MCP-1, IL-2, IL-6 and IL-10 were seen in both groups but IL-1ß and LIF were primarily upregulated in Wallerian degeneration of the whole nerve and not in capsaicin-induced degeneration of unmyelinated axons. The activated macrophage response, as measured by an increase in ED-1 immunostaining, was more prominent in the transected sciatic nerves compared to capsaicin-treated nerves. These findings indicate that there are differences in the cytokine and chemokine response of myelinating and non-myelinating Schwann cells to loss of their axons, and add to a growing body of literature that points to greater heterogeneity among Schwann cells.

Original languageEnglish (US)
Pages (from-to)230-235
Number of pages6
JournalNeuroscience Letters
Volume430
Issue number3
DOIs
StatePublished - Jan 17 2008

Keywords

  • Capsaicin
  • Chemokine
  • Myelinated axon
  • Schwann cell
  • Unmyelinated axon
  • Wallerian degeneration

ASJC Scopus subject areas

  • Neuroscience(all)

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