Abstract
Changes in cytokine and chemokine expression during Wallerian degeneration have been studied using nerve transection models, which result in denervation of both myelinating and non-myelinating Schwann cells. Cytokine and chemokine response of non-myelinating Remak Schwann cells to loss of their axons is unknown. In this study, we compared the expression profile of various cytokines and chemokines in distal nerves after capsaicin-induced degeneration of unmyelinated axons to Wallerian degeneration induced by nerve transection. Upregulation of MCP-1, IL-2, IL-6 and IL-10 were seen in both groups but IL-1ß and LIF were primarily upregulated in Wallerian degeneration of the whole nerve and not in capsaicin-induced degeneration of unmyelinated axons. The activated macrophage response, as measured by an increase in ED-1 immunostaining, was more prominent in the transected sciatic nerves compared to capsaicin-treated nerves. These findings indicate that there are differences in the cytokine and chemokine response of myelinating and non-myelinating Schwann cells to loss of their axons, and add to a growing body of literature that points to greater heterogeneity among Schwann cells.
Original language | English (US) |
---|---|
Pages (from-to) | 230-235 |
Number of pages | 6 |
Journal | Neuroscience Letters |
Volume | 430 |
Issue number | 3 |
DOIs | |
State | Published - Jan 17 2008 |
Keywords
- Capsaicin
- Chemokine
- Myelinated axon
- Schwann cell
- Unmyelinated axon
- Wallerian degeneration
ASJC Scopus subject areas
- Neuroscience(all)