Comparison of cyclooxygenase 2 expression in adenocarcinomas of the gastric cardia and distal oesophagus

C. J. Buskens, A. Sivula, B. P. Van Rees, C. Haglund, G. J A Offerhaus, J. J B Van Lanschot, A. Ristimäki

Research output: Contribution to journalArticle

Abstract

Background: Adenocarcinomas of the gastric cardia and distal oesophagus are at present often considered as one clinical entity because of their comparable increasing incidence, prognosis, and optimal treatment options. However, it is still a matter of debate whether these malignancies have the same pathogenesis and genotype. Aims: The aim of this study was to analyse expression of cyclooxygenase 2 (COX-2) in cardia carcinomas, and correlate this expression with clinicopathological parameters and survival. The results were compared with the prognostic value of COX-2 found for Barrett carcinomas. Methods: Tumour sections of 134 consecutive patients undergoing potentially curative surgery for an adenocarcinoma of the gastric cardia and substantially invading the distal oesophagus were immunohistochemically stained using a COX-2 monoclonal antibody. Specimens were blindly scored based on intensity and extent of COX-2 immunopositivity. Results: COX-2 expression was negative to weak in 59% ("COX-2 low") and moderate to strong in 41% ("COX-2 high") of tumours. This was significantly lower than in Barrett carcinomas (p

Original languageEnglish (US)
Pages (from-to)1678-1683
Number of pages6
JournalGut
Volume52
Issue number12
DOIs
StatePublished - Dec 2003
Externally publishedYes

ASJC Scopus subject areas

  • Gastroenterology

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