TY - JOUR
T1 - Comparison of commercial antimicrobial susceptibility test methods for testing of staphylococcus aureus and enterococci against vancomycin, daptomycin, and linezolid
AU - Riedel, Stefan
AU - Neoh, Kar Mun
AU - Eisinger, Stephen W.
AU - Dam, Lisa M.
AU - Tekle, Tsigereda
AU - Carrolla, Karen C.
PY - 2014/6
Y1 - 2014/6
N2 - Three commercial antimicrobial susceptibility testing (AST) methods were compared to broth microdilution for testing of Staphylococcus aureus and enterococci against vancomycin, daptomycin, and linezolid. Despite high levels of categorical agreement and essential agreement, vancomycin MICs determined by MicroScan were often 1 log2 concentration higher and MICs determined by Phoenix 1 log2 concentration lower. Daptomycin MICs were 1 to 2 log2 concentrations higher by all AST methods, except Etest, potentially impacting definitive antimicrobial therapy for bloodstream infections due to these organisms.
AB - Three commercial antimicrobial susceptibility testing (AST) methods were compared to broth microdilution for testing of Staphylococcus aureus and enterococci against vancomycin, daptomycin, and linezolid. Despite high levels of categorical agreement and essential agreement, vancomycin MICs determined by MicroScan were often 1 log2 concentration higher and MICs determined by Phoenix 1 log2 concentration lower. Daptomycin MICs were 1 to 2 log2 concentrations higher by all AST methods, except Etest, potentially impacting definitive antimicrobial therapy for bloodstream infections due to these organisms.
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U2 - 10.1128/JCM.00957-14
DO - 10.1128/JCM.00957-14
M3 - Article
C2 - 24719445
AN - SCOPUS:84901660833
SN - 0095-1137
VL - 52
SP - 2216
EP - 2222
JO - Journal of clinical microbiology
JF - Journal of clinical microbiology
IS - 6
ER -