Comparison of commercial antimicrobial susceptibility test methods for testing of staphylococcus aureus and enterococci against vancomycin, daptomycin, and linezolid

Stefan Riedel, Kar Mun Neoh, Stephen W. Eisinger, Lisa M. Dam, Tsigereda Tekle, Karen C. Carrolla

Research output: Contribution to journalArticle

Abstract

Three commercial antimicrobial susceptibility testing (AST) methods were compared to broth microdilution for testing of Staphylococcus aureus and enterococci against vancomycin, daptomycin, and linezolid. Despite high levels of categorical agreement and essential agreement, vancomycin MICs determined by MicroScan were often 1 log2 concentration higher and MICs determined by Phoenix 1 log2 concentration lower. Daptomycin MICs were 1 to 2 log2 concentrations higher by all AST methods, except Etest, potentially impacting definitive antimicrobial therapy for bloodstream infections due to these organisms.

Original languageEnglish (US)
Pages (from-to)2216-2222
Number of pages7
JournalJournal of clinical microbiology
Volume52
Issue number6
DOIs
StatePublished - Jun 2014

ASJC Scopus subject areas

  • Microbiology (medical)

Fingerprint Dive into the research topics of 'Comparison of commercial antimicrobial susceptibility test methods for testing of staphylococcus aureus and enterococci against vancomycin, daptomycin, and linezolid'. Together they form a unique fingerprint.

  • Cite this