TY - JOUR
T1 - Comparison of ChitoFlex®, CELOX™, and QuikClot® in control of hemorrhage
AU - Devlin, John J.
AU - Kircher, Sara
AU - Kozen, Buddy G.
AU - Littlejohn, Lanny F.
AU - Johnson, Andrew S.
N1 - Funding Information:
This study was funded by HemCon Medical Technologies, Inc. (CRADA 2542). None of the authors have received salary from the funding company. None of the authors are spokespersons for, paid consultants for, or stockholders in the funding company. The authors thank the nursing and hospital corpstaff of the Department of Emergency Medicine and the veterinary staff of the Clinical Investigations and Research Department, Naval Medical Center Portsmouth, VA. The authors would also like to thank Petty Officer Tanya Zamarripa for her logistical support and Dr. John Kircher for his statistical assistance.
PY - 2011/9
Y1 - 2011/9
N2 - Background: Exsanguinating extremity wounds remain the primary source of battlefield mortality. Operating forces employ three agents in Iraq: HemCon® (HemCon Medical Technologies, Inc., Portland, OR), QuikClot® (Z-Medica Corporation, Wallingford, CT), and CELOX™ (SAM Medical, Tualatin, OR). Anecdotal reports suggest that these agents are less useful on small entrance, linear-tract injuries. ChitoFlex® (HemCon Medical Technologies, Inc., Portland, OR) has been introduced but is untested. Study Objectives: To compare the equivalency of the ChitoFlex® dressing, QuikClot® ACS+™ dressing, CELOX™, and standard gauze in their effectiveness to control bleeding from non-cavitary groin wounds. Methods: Forty-eight swine were randomly assigned to one of four treatment groups: standard gauze dressing (SD), ChitoFlex® dressing (CF), QuikClot® ACS+™ dressing (QC), and CELOX™ dressing (CX). A groin injury with limited vessel access was created in each animal. Subjects were resuscitated with 500 mL of hetastarch. The primary endpoint was 180-min survival. Secondary endpoints included total blood loss in mL/kg, incidence of re-bleeding, survival times among the animals that did not survive for 180 min, failure to achieve initial hemostasis, incidence of recurrent bleeding, time to initial re-bleeding, amount of re-bleeding, and mass of residual hematoma. Results: Survival occurred in 10 of 12 SD animals, 10 of 12 CF animals, 10 of 12 QC animals, and 9 of 12 CX animals. No statistically significant difference was found. Conclusion: In our study of limited-access extremity bleeding, ChitoFlex® performed equally well in mitigating blood loss and promoting survival. The ChitoFlex® dressing is an equally effective alternative to currently available hemostatic agents. However, no agents were superior to standard gauze in our model of limited access.
AB - Background: Exsanguinating extremity wounds remain the primary source of battlefield mortality. Operating forces employ three agents in Iraq: HemCon® (HemCon Medical Technologies, Inc., Portland, OR), QuikClot® (Z-Medica Corporation, Wallingford, CT), and CELOX™ (SAM Medical, Tualatin, OR). Anecdotal reports suggest that these agents are less useful on small entrance, linear-tract injuries. ChitoFlex® (HemCon Medical Technologies, Inc., Portland, OR) has been introduced but is untested. Study Objectives: To compare the equivalency of the ChitoFlex® dressing, QuikClot® ACS+™ dressing, CELOX™, and standard gauze in their effectiveness to control bleeding from non-cavitary groin wounds. Methods: Forty-eight swine were randomly assigned to one of four treatment groups: standard gauze dressing (SD), ChitoFlex® dressing (CF), QuikClot® ACS+™ dressing (QC), and CELOX™ dressing (CX). A groin injury with limited vessel access was created in each animal. Subjects were resuscitated with 500 mL of hetastarch. The primary endpoint was 180-min survival. Secondary endpoints included total blood loss in mL/kg, incidence of re-bleeding, survival times among the animals that did not survive for 180 min, failure to achieve initial hemostasis, incidence of recurrent bleeding, time to initial re-bleeding, amount of re-bleeding, and mass of residual hematoma. Results: Survival occurred in 10 of 12 SD animals, 10 of 12 CF animals, 10 of 12 QC animals, and 9 of 12 CX animals. No statistically significant difference was found. Conclusion: In our study of limited-access extremity bleeding, ChitoFlex® performed equally well in mitigating blood loss and promoting survival. The ChitoFlex® dressing is an equally effective alternative to currently available hemostatic agents. However, no agents were superior to standard gauze in our model of limited access.
KW - combat
KW - hemorrhage
KW - hemostatic agent
KW - swine
KW - trauma
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UR - http://www.scopus.com/inward/citedby.url?scp=80052772516&partnerID=8YFLogxK
U2 - 10.1016/j.jemermed.2009.02.017
DO - 10.1016/j.jemermed.2009.02.017
M3 - Article
C2 - 19345045
AN - SCOPUS:80052772516
SN - 0736-4679
VL - 41
SP - 237
EP - 245
JO - Journal of Emergency Medicine
JF - Journal of Emergency Medicine
IS - 3
ER -