Comparison of channelized hotelling and human observers in determining optimum OS-EM reconstruction parameters for myocardial SPECT

Karen L. Gilland, Benjamin Tsui, Yujin Qi, Grant T. Gullberg

Research output: Contribution to journalArticle

Abstract

The performance of the Channelized Hotelling Observer (CHO) was compared to that of human observers for determining optimum parameters for the iterative OS-EM image reconstruction method for the task of defect detection in myocardial SPECT images. The optimum parameters were those that maximized defect detectability in the SPECT images. Low noise, parallel SPECT projection data, with and without an anterior, inferior or lateral LV wall defect, were simulated using the Monte Carlo method. Poisson noise was added to generate noisy realizations. Data were reconstructed using OS-EM at 1 & 4 subsets/iteration and at 1,3,5,7 & 9 iterations. Images were converted to 2D short-axis slices with integer pixel values. The CHO used 3 radially-symmetric, 2D channels, with varying levels of internal observer noise. For each parameter setting, 600 defect-present and 600 defect-absent image vectors were used to calculate the detectability index (d A). The human observers rated the likelihood that a defect was present in a specified location. For each parameter setting, the AUC was estimated from 48 defect-present and 48 defect-absent images. The combined human observer results showed the optimum parameter setting could be in the range 5-36 updates ([number of subsetsj/iteration × number of iterations). The CHO results showed the optimum parameter setting to be 4-5 updates. The performance of the CHO was much more sensitive to the reconstruction parameter setting than was that of the human observers. The rankings of the CHO detectability values did not change with varying levels of internal noise.

Original languageEnglish (US)
Article number1645016
Pages (from-to)1200-1204
Number of pages5
JournalIEEE Transactions on Nuclear Science
Volume53
Issue number3
DOIs
StatePublished - Jun 2006

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Defects
defects
iteration
ranking
Image reconstruction
image reconstruction
low noise
Monte Carlo methods
set theory
integers
Monte Carlo method
Pixels
projection
pixels

ASJC Scopus subject areas

  • Electrical and Electronic Engineering
  • Nuclear Energy and Engineering

Cite this

Comparison of channelized hotelling and human observers in determining optimum OS-EM reconstruction parameters for myocardial SPECT. / Gilland, Karen L.; Tsui, Benjamin; Qi, Yujin; Gullberg, Grant T.

In: IEEE Transactions on Nuclear Science, Vol. 53, No. 3, 1645016, 06.2006, p. 1200-1204.

Research output: Contribution to journalArticle

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