Comparison of changes in corneal endothelial cell density and central corneal thickness between conventional and femtosecond laser-assisted cataract surgery: A randomised, controlled clinical trial

Daliya Dzhaber, Osama Mustafa, Fares Alsaleh, Aleksandra Mihailovic, Yassine J. Daoud

Research output: Contribution to journalArticle

Abstract

Background/Aim To identify changes in endothelial cell density (ECD) and central corneal thickness (CCT) in eyes undergoing femtosecond laser-assisted cataract surgery (FLACS) compared with conventional phacoemulsification surgery (CPS). Methods This is an intraindividual randomised, controlled clinical trial. One eye was randomised to receive FLACS, while the contralateral eye of the same patient received CPS. The femtosecond laser pretreatment included creating main and side-port corneal incisions, capsulotomy and lens fragmentation. Non-contact endothelial cell microscopy and pachymetry were performed preoperatively and at postoperative day 1, week 1, month 1 and month 3. Results A total of 134 paired eyes from 67 patients were included in the analysis. ECD was not significantly different between the two groups at either postoperative month 1 (2370±580 cells/mm 2 and 2467±564 cells/mm 2 in FLACS and CPS groups, respectively; p=0.18) or at postoperative month 3 (2374±527 cells/mm 2 and 2433±526 cells/mm 2 in FLACS and CPS groups, respectively; p=0.19). No significant difference was observed in the mean CCT values between the two groups over the follow-up period (p>0.05). Conclusion Postoperative corneal ECD and CCT were comparable between FLACS and CPS during the 3 months' follow-up period.

Original languageEnglish (US)
Pages (from-to)225-229
Number of pages5
JournalBritish Journal of Ophthalmology
Volume104
Issue number2
DOIs
StatePublished - Feb 1 2020

Keywords

  • ECD
  • FLACS
  • corneal thickness
  • endothelial cell density
  • femtosecond laser
  • phacoemulsification

ASJC Scopus subject areas

  • Ophthalmology
  • Sensory Systems
  • Cellular and Molecular Neuroscience

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