TY - JOUR
T1 - Comparison of changes in corneal endothelial cell density and central corneal thickness between conventional and femtosecond laser-assisted cataract surgery
T2 - A randomised, controlled clinical trial
AU - Dzhaber, Daliya
AU - Mustafa, Osama
AU - Alsaleh, Fares
AU - Mihailovic, Aleksandra
AU - Daoud, Yassine J.
N1 - Funding Information:
Funding Unrestricted research grants from the Michael O’Bannon Foundation and the Turner Family.
Publisher Copyright:
© Author(s) (or their employer(s)) 2020. No commercial re-use. See rights and permissions. Published by BMJ.
PY - 2020/2/1
Y1 - 2020/2/1
N2 - Background/Aim To identify changes in endothelial cell density (ECD) and central corneal thickness (CCT) in eyes undergoing femtosecond laser-assisted cataract surgery (FLACS) compared with conventional phacoemulsification surgery (CPS). Methods This is an intraindividual randomised, controlled clinical trial. One eye was randomised to receive FLACS, while the contralateral eye of the same patient received CPS. The femtosecond laser pretreatment included creating main and side-port corneal incisions, capsulotomy and lens fragmentation. Non-contact endothelial cell microscopy and pachymetry were performed preoperatively and at postoperative day 1, week 1, month 1 and month 3. Results A total of 134 paired eyes from 67 patients were included in the analysis. ECD was not significantly different between the two groups at either postoperative month 1 (2370±580 cells/mm 2 and 2467±564 cells/mm 2 in FLACS and CPS groups, respectively; p=0.18) or at postoperative month 3 (2374±527 cells/mm 2 and 2433±526 cells/mm 2 in FLACS and CPS groups, respectively; p=0.19). No significant difference was observed in the mean CCT values between the two groups over the follow-up period (p>0.05). Conclusion Postoperative corneal ECD and CCT were comparable between FLACS and CPS during the 3 months' follow-up period.
AB - Background/Aim To identify changes in endothelial cell density (ECD) and central corneal thickness (CCT) in eyes undergoing femtosecond laser-assisted cataract surgery (FLACS) compared with conventional phacoemulsification surgery (CPS). Methods This is an intraindividual randomised, controlled clinical trial. One eye was randomised to receive FLACS, while the contralateral eye of the same patient received CPS. The femtosecond laser pretreatment included creating main and side-port corneal incisions, capsulotomy and lens fragmentation. Non-contact endothelial cell microscopy and pachymetry were performed preoperatively and at postoperative day 1, week 1, month 1 and month 3. Results A total of 134 paired eyes from 67 patients were included in the analysis. ECD was not significantly different between the two groups at either postoperative month 1 (2370±580 cells/mm 2 and 2467±564 cells/mm 2 in FLACS and CPS groups, respectively; p=0.18) or at postoperative month 3 (2374±527 cells/mm 2 and 2433±526 cells/mm 2 in FLACS and CPS groups, respectively; p=0.19). No significant difference was observed in the mean CCT values between the two groups over the follow-up period (p>0.05). Conclusion Postoperative corneal ECD and CCT were comparable between FLACS and CPS during the 3 months' follow-up period.
KW - ECD
KW - FLACS
KW - corneal thickness
KW - endothelial cell density
KW - femtosecond laser
KW - phacoemulsification
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U2 - 10.1136/bjophthalmol-2018-313723
DO - 10.1136/bjophthalmol-2018-313723
M3 - Article
C2 - 31097441
AN - SCOPUS:85065838510
SN - 0007-1161
VL - 104
SP - 225
EP - 229
JO - British Journal of Ophthalmology
JF - British Journal of Ophthalmology
IS - 2
ER -