Comparison of brain white matter fiber orientation measurements based on diffusion tensor imaging and light microscopy

Adam W. Anderson; Ann S. Choe; Iwona Stepniewska; Daniel C. Colvin

doi:10.1109/IEMBS.2006.259554

Comparison of brain white matter fiber orientation measurements based on diffusion tensor imaging and light microscopy

Adam W. Anderson, Ann S. Choe, Iwona Stepniewska, Daniel C. Colvin

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

4 Scopus citations

Abstract

Diffusion tensor magnetic resonance imaging (MRI) was used to estimate white matter fiber orientations in fixed brain specimens. The specimens were subsequently sectioned, stained for myelinated fibers, and imaged with light microscopy. The MRI data were registered with the micrographs, allowing direct comparison of fiber orientation estimates between the two methods. Fiber orientation was measured in regions of interest in the frontal lateral corpus callosum. The results of diffusion MRI and light microscopy agreed within 2 degrees-the difference was not statistically significant.

Original language	English (US)
Title of host publication	28th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS'06
Pages	2249-2251
Number of pages	3
DOIs	https://doi.org/10.1109/IEMBS.2006.259554
State	Published - 2006
Externally published	Yes
Event	28th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS'06 - New York, NY, United States Duration: Aug 30 2006 → Sep 3 2006

Publication series

Name	Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings
ISSN (Print)	0589-1019

Other

Other	28th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS'06
Country/Territory	United States
City	New York, NY
Period	8/30/06 → 9/3/06

ASJC Scopus subject areas

Signal Processing
Biomedical Engineering
Computer Vision and Pattern Recognition
Health Informatics

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10.1109/IEMBS.2006.259554

Cite this

Anderson, A. W., Choe, A. S., Stepniewska, I., & Colvin, D. C. (2006). Comparison of brain white matter fiber orientation measurements based on diffusion tensor imaging and light microscopy. In 28th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS'06 (pp. 2249-2251). Article 4030524 (Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings). https://doi.org/10.1109/IEMBS.2006.259554

Comparison of brain white matter fiber orientation measurements based on diffusion tensor imaging and light microscopy. / Anderson, Adam W.; Choe, Ann S.; Stepniewska, Iwona et al.
28th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS'06. 2006. p. 2249-2251 4030524 (Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Anderson, AW, Choe, AS, Stepniewska, I & Colvin, DC 2006, Comparison of brain white matter fiber orientation measurements based on diffusion tensor imaging and light microscopy. in 28th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS'06., 4030524, Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings, pp. 2249-2251, 28th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS'06, New York, NY, United States, 8/30/06. https://doi.org/10.1109/IEMBS.2006.259554

Anderson AW, Choe AS, Stepniewska I, Colvin DC. Comparison of brain white matter fiber orientation measurements based on diffusion tensor imaging and light microscopy. In 28th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS'06. 2006. p. 2249-2251. 4030524. (Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings). doi: 10.1109/IEMBS.2006.259554

Anderson, Adam W. ; Choe, Ann S. ; Stepniewska, Iwona et al. / Comparison of brain white matter fiber orientation measurements based on diffusion tensor imaging and light microscopy. 28th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS'06. 2006. pp. 2249-2251 (Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings).

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abstract = "Diffusion tensor magnetic resonance imaging (MRI) was used to estimate white matter fiber orientations in fixed brain specimens. The specimens were subsequently sectioned, stained for myelinated fibers, and imaged with light microscopy. The MRI data were registered with the micrographs, allowing direct comparison of fiber orientation estimates between the two methods. Fiber orientation was measured in regions of interest in the frontal lateral corpus callosum. The results of diffusion MRI and light microscopy agreed within 2 degrees-the difference was not statistically significant.",

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Comparison of brain white matter fiber orientation measurements based on diffusion tensor imaging and light microscopy

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