Comparison of brain white matter fiber orientation measurements based on diffusion tensor imaging and light microscopy

Adam W. Anderson, Ann S. Choe, Iwona Stepniewska, Daniel C. Colvin

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Diffusion tensor magnetic resonance imaging (MRI) was used to estimate white matter fiber orientations in fixed brain specimens. The specimens were subsequently sectioned, stained for myelinated fibers, and imaged with light microscopy. The MRI data were registered with the micrographs, allowing direct comparison of fiber orientation estimates between the two methods. Fiber orientation was measured in regions of interest in the frontal lateral corpus callosum. The results of diffusion MRI and light microscopy agreed within 2 degrees-the difference was not statistically significant.

Original languageEnglish (US)
Title of host publication28th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS'06
Pages2249-2251
Number of pages3
DOIs
StatePublished - 2006
Externally publishedYes
Event28th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS'06 - New York, NY, United States
Duration: Aug 30 2006Sep 3 2006

Publication series

NameAnnual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings
ISSN (Print)0589-1019

Other

Other28th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS'06
CountryUnited States
CityNew York, NY
Period8/30/069/3/06

ASJC Scopus subject areas

  • Signal Processing
  • Biomedical Engineering
  • Computer Vision and Pattern Recognition
  • Health Informatics

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