Comparison of apparent diffusion coefficients and distributed diffusion coefficients in high-grade gliomas

Thomas C. Kwee, Craig J. Galbán, Christina Tsien, Larry Junck, Pia C. Sundgren, Marko K. Ivancevic, Timothy D. Johnson, Charles R. Meyer, Alnawaz Rehemtulla, Brian D. Ross, Thomas L. Chenevert

Research output: Contribution to journalArticlepeer-review


Purpose: To compare apparent diffusion coefficients (ADCs) with distributed diffusion coefficients (DDCs) in high-grade gliomas. Materials and Methods: Twenty patients with high-grade gliomas prospectively underwent diffusion-weighted MRI. Traditional ADC maps were created using b-values of 0 and 1000 s/mm2. In addition, DDC maps were created by applying the stretched-exponential model using b-values of 0, 1000, 2000, and 4000 s/mm 2. Whole-tumor ADCs and DDCs (in 10-3 mm2/s) were measured and analyzed with a paired t-test, Pearson's correlation coefficient, and the Bland-Altman method. Results: Tumor ADCs (1.14 ± 0.26) were significantly lower (P = 0.0001) than DDCs (1.64 ± 0.71). Tumor ADCs and DDCs were strongly correlated (R = 0.9716; P < 0.0001), but mean bias 6 limits of agreement between tumor ADCs and DDCs was -0.50 ± 0.90. There was a clear trend toward greater discordance between ADC and DDC at high ADC values. Conclusion: Under the assumption that the stretched-exponential model provides a more accurate estimate of the average diffusion rate than the mono-exponential model, our results suggest that for a little diffusion attenuation the mono-exponential fit works rather well for quantifying diffusion in high-grade gliomas, whereas it works less well for a greater degree of diffusion attenuation.

Original languageEnglish (US)
Pages (from-to)531-537
Number of pages7
JournalJournal of Magnetic Resonance Imaging
Issue number3
StatePublished - Mar 2010
Externally publishedYes


  • Apparent diffusion coefficient
  • Brain tumor
  • Diffusion-weighted magnetic resonance imaging
  • Distributed diffusion coefficient
  • Glioma
  • Stretched-exponential

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging


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