TY - JOUR
T1 - Comparison of Aortic Arch and Intravenous Contrast Injection Techniques for C-arm Cone Beam CT. Implications for Cerebral Perfusion Imaging in the Angiography Suite.
AU - Klostranec, Jesse M.
AU - Ehtiati, Tina
AU - Rao, Swati
AU - Radvany, Martin G.
N1 - Funding Information:
Dawn Ruben, DVM, for taking care of the animals and putting up with our late nights. Beatriz Kohler, RN, MBA, for coordinating our crazy and erratic schedules and getting everyone together in the same place so we could perform our studies. The reviewers for their helpful critique of the manuscript. M.G.R. receives research support from Siemens Healthcare.
PY - 2013/4
Y1 - 2013/4
N2 - Rationale and Objectives: The ability to perform cerebral perfusion imaging (CPI) in the angiography suite has provided a new tool for diagnosis and treatment of neurovascular patients but requires comparable contrast perfusion to each cerebral hemisphere. In the angiography suite, contrast injection may be performed via an intra-arterial or intravenous (IV) route. The purpose of this study was to investigate whether a difference exists between contrast injection in the aortic arch (AA) and a peripheral vein (IV), particularly in the setting of stroke. Materials and Methods: Using three canines, both AA and IV injection protocols compatible with CPI were performed prospectively at three time points after creation of a stroke. The common carotid arteries in the resulting image data sets were segmented and the means and distributions of corresponding pixel intensities analyzed with Student's t-test. Using similar techniques, the internal carotid arteries of three patients (one female, two males, ages 69, 29, and 20) undergoing AA contrast injection with cone beam computed tomography (CBCT) cerebral imaging were analyzed and compared retrospectively with those of three random patients (one female, two males, ages 19, 57, and 35) undergoing standard head CT scans using IV contrast administration. All acquisitions followed institutionally approved protocols and informed consent. Results: No statistical significance (P <.05) was found when mean values for the right and left carotid artery pixel intensities were compared in the canine model or the clinical studies in which patients underwent imaging after AA or IV contrast administration. Conclusions: No statistically significant difference exists between right and left carotid artery filling density using either AA or IV contrast injection methods, making both suitable for CPI in the angiography suite.
AB - Rationale and Objectives: The ability to perform cerebral perfusion imaging (CPI) in the angiography suite has provided a new tool for diagnosis and treatment of neurovascular patients but requires comparable contrast perfusion to each cerebral hemisphere. In the angiography suite, contrast injection may be performed via an intra-arterial or intravenous (IV) route. The purpose of this study was to investigate whether a difference exists between contrast injection in the aortic arch (AA) and a peripheral vein (IV), particularly in the setting of stroke. Materials and Methods: Using three canines, both AA and IV injection protocols compatible with CPI were performed prospectively at three time points after creation of a stroke. The common carotid arteries in the resulting image data sets were segmented and the means and distributions of corresponding pixel intensities analyzed with Student's t-test. Using similar techniques, the internal carotid arteries of three patients (one female, two males, ages 69, 29, and 20) undergoing AA contrast injection with cone beam computed tomography (CBCT) cerebral imaging were analyzed and compared retrospectively with those of three random patients (one female, two males, ages 19, 57, and 35) undergoing standard head CT scans using IV contrast administration. All acquisitions followed institutionally approved protocols and informed consent. Results: No statistical significance (P <.05) was found when mean values for the right and left carotid artery pixel intensities were compared in the canine model or the clinical studies in which patients underwent imaging after AA or IV contrast administration. Conclusions: No statistically significant difference exists between right and left carotid artery filling density using either AA or IV contrast injection methods, making both suitable for CPI in the angiography suite.
KW - Cerebral perfusion imaging
KW - Cone beam CT
KW - Contrast injection
KW - Stroke imaging
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U2 - 10.1016/j.acra.2012.10.008
DO - 10.1016/j.acra.2012.10.008
M3 - Article
C2 - 23498995
AN - SCOPUS:84875083861
SN - 1076-6332
VL - 20
SP - 509
EP - 518
JO - Academic radiology
JF - Academic radiology
IS - 4
ER -