Comparison of antibody reactivity to human immunodeficiency virus type 1 (HIV-1) gp160 epitopes in sera from HIV-1-infected individuals from Tanzania and from the United States

R. Q. Warren, W. M M M Nkya, J. F. Shoa, S. A. Anderson, H. Wolf, Craig Hendrix, P. Kanda, M. Wabuke, R. N. Boswell, R. R. Redfield, R. C. Kennedy

Research output: Contribution to journalArticle

Abstract

In this study, we compared sera from 159 human immunodeficiency virus type 1 (HIV-1)-infected individuals from Tanzania and 103 infected individuals from the United States for antibodies reactive with 10 HIV-1 gp160 epitopes defined by synthetic peptides. Our data indicate that the anti-gp160 antibody fine specificity differs between infected individuals from these two geographically diverse populations. For example, 50% of the Tanzanian sera contained antibodies reactive with an immunodominant HIV-1 gp41 epitope defined by peptide 600-611, whereas 91% of the sera from the United States were reactive. Differences in serologic reactivity between HIV-1-infected individuals from Tanzania and the United States were also observed with gp160 epitopes defined by peptides 503-528 and 846-860. Included among the peptides examined were four which corresponded to the V3 region of gp120. The majority of sera from either country contained antibodies reactive with peptide RP142, whose V3 sequence is based upon that of HIV-1 isolate MN. Further characterization of serologic reactivity suggested that sera from Tanzania were more likely to neutralize HIV-1 isolate IIIB or MN in vitro than were sera from the United States. These differences in antibody fine specificity between HIV-1-infected individuals from Tanzania and the United States suggest that regional isolates of HIV-1 may exist.

Original languageEnglish (US)
Pages (from-to)126-131
Number of pages6
JournalJournal of Clinical Microbiology
Volume30
Issue number1
StatePublished - 1992
Externally publishedYes

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Tanzania
HIV-1
Epitopes
Antibodies
Serum
Peptides
Antibody Specificity
Anti-Idiotypic Antibodies

ASJC Scopus subject areas

  • Microbiology
  • Microbiology (medical)

Cite this

Comparison of antibody reactivity to human immunodeficiency virus type 1 (HIV-1) gp160 epitopes in sera from HIV-1-infected individuals from Tanzania and from the United States. / Warren, R. Q.; Nkya, W. M M M; Shoa, J. F.; Anderson, S. A.; Wolf, H.; Hendrix, Craig; Kanda, P.; Wabuke, M.; Boswell, R. N.; Redfield, R. R.; Kennedy, R. C.

In: Journal of Clinical Microbiology, Vol. 30, No. 1, 1992, p. 126-131.

Research output: Contribution to journalArticle

Warren, RQ, Nkya, WMMM, Shoa, JF, Anderson, SA, Wolf, H, Hendrix, C, Kanda, P, Wabuke, M, Boswell, RN, Redfield, RR & Kennedy, RC 1992, 'Comparison of antibody reactivity to human immunodeficiency virus type 1 (HIV-1) gp160 epitopes in sera from HIV-1-infected individuals from Tanzania and from the United States', Journal of Clinical Microbiology, vol. 30, no. 1, pp. 126-131.
Warren, R. Q. ; Nkya, W. M M M ; Shoa, J. F. ; Anderson, S. A. ; Wolf, H. ; Hendrix, Craig ; Kanda, P. ; Wabuke, M. ; Boswell, R. N. ; Redfield, R. R. ; Kennedy, R. C. / Comparison of antibody reactivity to human immunodeficiency virus type 1 (HIV-1) gp160 epitopes in sera from HIV-1-infected individuals from Tanzania and from the United States. In: Journal of Clinical Microbiology. 1992 ; Vol. 30, No. 1. pp. 126-131.
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