Abstract
The sensitivity and specificity of alternate analytic strategies for recognizing glaucomatous visual field loss from automated threshold perimetry (C-30-2 test of the Humphrey Field Analyzer) were compared among one eye each of 106 patients with glaucoma and 249 normal subjects. Algorithms included commercially available global indexes and cross-meridional differences (Statpac 1 and Statpac 2), as well as cross-meridional and cluster analyses that were developed independently for natural history studies and clinical trials. The sensitivity of most algorithms was high, except for those that used only diffuse loss as an indicator of abnormality. Specificity was acceptably high for all algorithms. Subjects who failed to meet the manufacturer's standard for reliability had much reduced specificity, but sensitivity was also affected. Algorithms that were based on any of the alternate definitions of localized reduction in retinal sensitivity performed equally well, which suggests that any of these approaches is useful in searching for glaucomatous visual loss as typified by this database. Availability, familiarity, and convenience may govern the selection of any one analytic approach for use in a particular setting.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1684-1689 |
| Number of pages | 6 |
| Journal | Archives of Ophthalmology |
| Volume | 109 |
| Issue number | 12 |
| DOIs | |
| State | Published - 1991 |
Fingerprint
ASJC Scopus subject areas
- Ophthalmology
Cite this
Comparison of Analytic Algorithms for Detecting Glaucomatous Visual Field Loss. / Katz, Joanne; Sommer, Alfred; Gaasterland, Douglas E.; Anderson, Douglas R.
In: Archives of Ophthalmology, Vol. 109, No. 12, 1991, p. 1684-1689.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Comparison of Analytic Algorithms for Detecting Glaucomatous Visual Field Loss
AU - Katz, Joanne
AU - Sommer, Alfred
AU - Gaasterland, Douglas E.
AU - Anderson, Douglas R.
PY - 1991
Y1 - 1991
N2 - The sensitivity and specificity of alternate analytic strategies for recognizing glaucomatous visual field loss from automated threshold perimetry (C-30-2 test of the Humphrey Field Analyzer) were compared among one eye each of 106 patients with glaucoma and 249 normal subjects. Algorithms included commercially available global indexes and cross-meridional differences (Statpac 1 and Statpac 2), as well as cross-meridional and cluster analyses that were developed independently for natural history studies and clinical trials. The sensitivity of most algorithms was high, except for those that used only diffuse loss as an indicator of abnormality. Specificity was acceptably high for all algorithms. Subjects who failed to meet the manufacturer's standard for reliability had much reduced specificity, but sensitivity was also affected. Algorithms that were based on any of the alternate definitions of localized reduction in retinal sensitivity performed equally well, which suggests that any of these approaches is useful in searching for glaucomatous visual loss as typified by this database. Availability, familiarity, and convenience may govern the selection of any one analytic approach for use in a particular setting.
AB - The sensitivity and specificity of alternate analytic strategies for recognizing glaucomatous visual field loss from automated threshold perimetry (C-30-2 test of the Humphrey Field Analyzer) were compared among one eye each of 106 patients with glaucoma and 249 normal subjects. Algorithms included commercially available global indexes and cross-meridional differences (Statpac 1 and Statpac 2), as well as cross-meridional and cluster analyses that were developed independently for natural history studies and clinical trials. The sensitivity of most algorithms was high, except for those that used only diffuse loss as an indicator of abnormality. Specificity was acceptably high for all algorithms. Subjects who failed to meet the manufacturer's standard for reliability had much reduced specificity, but sensitivity was also affected. Algorithms that were based on any of the alternate definitions of localized reduction in retinal sensitivity performed equally well, which suggests that any of these approaches is useful in searching for glaucomatous visual loss as typified by this database. Availability, familiarity, and convenience may govern the selection of any one analytic approach for use in a particular setting.
UR - http://www.scopus.com/inward/record.url?scp=0026410735&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0026410735&partnerID=8YFLogxK
U2 - 10.1001/archopht.1991.01080120068028
DO - 10.1001/archopht.1991.01080120068028
M3 - Article
VL - 109
SP - 1684
EP - 1689
JO - JAMA Ophthalmology
JF - JAMA Ophthalmology
SN - 2168-6165
IS - 12
ER -