TY - JOUR
T1 - Comparison of Alzheimer's disease risk factors in white and African American families
AU - Bachman, D. L.
AU - Green, R. C.
AU - Benke, K. S.
AU - Cupples, L. A.
AU - Farrer, Lindsay A.
PY - 2003/4/22
Y1 - 2003/4/22
N2 - The associations between alcohol, smoking, and head injury and the risk of AD in 443 African American and 2,336 white participants in the MIRAGE Study were evaluated. Alcohol had a modest protective effect in whites (odds ratio [OR] = 0.82, 95% CI = 0.68 to 0.99), with a similar trend in African Americans (OR = 0.88, 95% CI = 0.54 to 1.4). Head trauma increased the risk of AD in whites (OR = 2.3, 95% CI = 1.8 to 3.0) and African Americans (OR = 2.9, 95% CI = 1.2 to 7.0). Smoking was not associated with AD risk in whites (OR = 0.88, 95% CI = 0.73 to 1.1) or African Americans (OR = 1.0, 95% CI = 0.69 to 1.5). These risks were similar across subsets stratified by the presence or absence of the APOE ε4 allele.
AB - The associations between alcohol, smoking, and head injury and the risk of AD in 443 African American and 2,336 white participants in the MIRAGE Study were evaluated. Alcohol had a modest protective effect in whites (odds ratio [OR] = 0.82, 95% CI = 0.68 to 0.99), with a similar trend in African Americans (OR = 0.88, 95% CI = 0.54 to 1.4). Head trauma increased the risk of AD in whites (OR = 2.3, 95% CI = 1.8 to 3.0) and African Americans (OR = 2.9, 95% CI = 1.2 to 7.0). Smoking was not associated with AD risk in whites (OR = 0.88, 95% CI = 0.73 to 1.1) or African Americans (OR = 1.0, 95% CI = 0.69 to 1.5). These risks were similar across subsets stratified by the presence or absence of the APOE ε4 allele.
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U2 - 10.1212/01.WNL.0000058751.43033.4D
DO - 10.1212/01.WNL.0000058751.43033.4D
M3 - Article
C2 - 12707449
AN - SCOPUS:0037461327
SN - 0028-3878
VL - 60
SP - 1372
EP - 1374
JO - Neurology
JF - Neurology
IS - 8
ER -