Comparison of Alzheimer's disease risk factors in white and African American families

D. L. Bachman, R. C. Green, K. S. Benke, L. A. Cupples, Lindsay A. Farrer

Research output: Contribution to journalArticle

Abstract

The associations between alcohol, smoking, and head injury and the risk of AD in 443 African American and 2,336 white participants in the MIRAGE Study were evaluated. Alcohol had a modest protective effect in whites (odds ratio [OR] = 0.82, 95% CI = 0.68 to 0.99), with a similar trend in African Americans (OR = 0.88, 95% CI = 0.54 to 1.4). Head trauma increased the risk of AD in whites (OR = 2.3, 95% CI = 1.8 to 3.0) and African Americans (OR = 2.9, 95% CI = 1.2 to 7.0). Smoking was not associated with AD risk in whites (OR = 0.88, 95% CI = 0.73 to 1.1) or African Americans (OR = 1.0, 95% CI = 0.69 to 1.5). These risks were similar across subsets stratified by the presence or absence of the APOE ε4 allele.

Original languageEnglish (US)
Pages (from-to)1372-1374
Number of pages3
JournalNeurology
Volume60
Issue number8
DOIs
StatePublished - Apr 22 2003

ASJC Scopus subject areas

  • Clinical Neurology

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