Comparison of adaptation motifs: Temporal, stochastic and spatial responses

Pablo A Iglesias, Changji Shi

Research output: Contribution to journalArticle

Abstract

The cells' ability to adapt to changes in the external environment is crucial for the survival of many organisms. There are two broad classes of signalling networks that achieve perfect adaptation. Both rely on complementary regulation of the response by an external signal and an inhibitory process. In one class of systems, inhibition comes about from the response itself, closing a negative feedback (NFB) loop. In the other, the inhibition comes directly from the external signal in what is referred to as an incoherent feedforward (IFF) loop. Although both systems show adaptive behaviour to constant changes in the level of the stimulus, their response to other forms of stimuli can differ. Here the authors consider the respective response to various such disturbances, including ramp increases, removal of the stimulus and pulses. The authors also consider the effect of stochastic fluctuations in signalling that come about from the interaction of the signalling elements. Finally, the authors consider the possible effect of spatially varying signals. The authors show that both the NFB and the IFF motifs can be used to sense static spatial gradients, under a local excitation, global inhibition assumption. The results may help experimentalists develop protocols that can discriminate between the two adaptation motifs.

Original languageEnglish (US)
Pages (from-to)268-281
Number of pages14
JournalIET Systems Biology
Volume8
Issue number6
DOIs
Publication statusPublished - Dec 1 2014

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ASJC Scopus subject areas

  • Biotechnology
  • Cell Biology
  • Genetics
  • Molecular Biology
  • Modeling and Simulation
  • Medicine(all)

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