Comparison of a supplemented Rose questionnaire to exercise thallium testing in men and women

Eric B. Bass, William P. Follansbee, Trevor J. Orchard

Research output: Contribution to journalArticlepeer-review


The Rose Questionnaire has had high specificity and variable sensitivity when compared to physician identification of the symptom complex of angina pectoris. We assessed the accuracy of a supplemented Rose Questionnaire in a series of 198 patients by comparing the Questionnaire to exercise thallium test evidence of coronary artery disease. The Rose diagnosis of angina had 26% sensitivity, 79% specificity, 42% positive predictive value, and 65% negative predictive value. The Rose diagnosis of myocardial infarction had 26% sensitivity and 90% specificity. The Rose diagnosis of angina or infarction yielded a sensitivity of 44%, specificity of 72%, positive predictive value of 67%, and negative predictive value of 50%. Supplemental questions designed to identify atypical ischemic pain led to increased sensitivity of up to 68% that was offset by decreased specificity. While the Questionnaire's sensitivity for coronary disease was greater for women than men (57 vs 40%), the overall accuracy was the same because specificity was lower (63 vs 80%).

Original languageEnglish (US)
Pages (from-to)385-394
Number of pages10
JournalJournal of Clinical Epidemiology
Issue number5
StatePublished - 1989
Externally publishedYes


  • Coronary disease
  • Rose Questionnaire
  • Thallium

ASJC Scopus subject areas

  • Epidemiology


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