Comparison of [11C]diprenorphine and [11C]carfentanil in vivo binding to opiate receptors in man using a dual detector system

Victor L. Villemagne, J. James Frost, Robert F Dannals, John R. Lever, Shuji Tanada, T. K. Natarajan, Alan A. Wilson, Hayden T. Ravert, Henry N. Wagner

Research output: Contribution to journalArticle

Abstract

A simple dual detector coincidence system was used to measure the binding of [11C]carfentanil and [11C]diprenorphine to opiate receptors in normal volunteers before and after the administration of naloxone. Total radioactivity without naloxone and the ratio of total/non-specific radioactivity was 2 times greater for [11C]diprenorphine than [11C]carfentanil. The dose of naloxone required to maximally block specific [11C]diprenorphine binding was 10 times that for [11C]carfentanil, indicating that [11C]diprenorphine labels opiate receptor subtypes in addition to μ opiate receptors.

Original languageEnglish (US)
Pages (from-to)195-197
Number of pages3
JournalEuropean Journal of Pharmacology
Volume257
Issue number1-2
DOIs
StatePublished - May 12 1994

Fingerprint

carfentanil
Diprenorphine
Opioid Receptors
Naloxone
Radioactivity
Healthy Volunteers

Keywords

  • Dual detector system
  • Opiate receptor
  • Positron emitting tracer

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience
  • Pharmacology

Cite this

Comparison of [11C]diprenorphine and [11C]carfentanil in vivo binding to opiate receptors in man using a dual detector system. / Villemagne, Victor L.; James Frost, J.; Dannals, Robert F; Lever, John R.; Tanada, Shuji; Natarajan, T. K.; Wilson, Alan A.; Ravert, Hayden T.; Wagner, Henry N.

In: European Journal of Pharmacology, Vol. 257, No. 1-2, 12.05.1994, p. 195-197.

Research output: Contribution to journalArticle

Villemagne, Victor L. ; James Frost, J. ; Dannals, Robert F ; Lever, John R. ; Tanada, Shuji ; Natarajan, T. K. ; Wilson, Alan A. ; Ravert, Hayden T. ; Wagner, Henry N. / Comparison of [11C]diprenorphine and [11C]carfentanil in vivo binding to opiate receptors in man using a dual detector system. In: European Journal of Pharmacology. 1994 ; Vol. 257, No. 1-2. pp. 195-197.
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