Comparison between diffusion-weighted imaging, T1-weighted, and postcontrast T1-weighted imaging after MR-guided, high intensity, focused ultrasound treatment of uterine leiomyomata: Preliminary results

Michael A. Jacobs, David H. Gultekin, Hyun S. Kim

Research output: Contribution to journalArticlepeer-review


Purpose: To investigate the comparison between diffusion-weighted imaging (DWI), T2 -weighted imaging, (T2 WI) and contrast T 1 -weighted imaging (cT1 WI) in uterine leiomyoma following treatment by magnetic resonance imaging-guided, high intensity focused ultrasound surgery (MRg-HIFUS). Methods: Twenty one patients (45±5 yrs) with clinical symptoms of uterine leiomyoma (fibroids) were treated by MRg-HIFUS using an integrated 1.5T MRI-HIFUS system. MRI parameters consisted of DWI, T2 WI, and T1 -weighted fast spoiled gradient echo before and after contrast. The post-MRg-HIFUS treatment volume in the fibroid was assessed by cT1 WI and DWI. Trace apparent diffusion coefficient maps were constructed for quantitative analysis. The regions of the treated uterine tissue were defined by a semisupervised segmentation method called the "eigenimage filter," using both cT1 WI and DWI. Signal-to-noise ratios were determined for the T2 WI pretreatment images. Segmented regions were tested by a similarity index for congruence. Descriptive, regression, and Bland-Altman statistics were calculated. Results: All the patients exhibited heterogeneously increased DWI signal intensity localized in the treated fibroid regions and were colocalized with the cT 1 WI defined area. The mean pretreatment T2 WI signal intensity ratios were T2 WI/muscle=1.8±0.7 and T2 WI/myometrium=0.7±0.4. The congruence between the regions was significant, with a similarity of 84% and a difference of 8% between the regions. Regression analyses of the cT1 WI and DWI segmented treatment volumes were found to be significantly correlated (r2 =0.94, p<0.05) with the linear equation, (cT1 WI) =1.1 (DWI) -0.66. There is good agreement between the regions defined by cT1WI and DWI in most of the cases as shown from the Bland-Altman plots. Conclusions: Diffusion-weighted imaging exhibited excellent agreement, congruence, and correlation with the cT1 WI -defined region of treatment in uterine fibroid. Therefore, DWI could be useful as an adjunct for assessing treatment of uterine fibroids by MRg-HIFUS.

Original languageEnglish (US)
Pages (from-to)4768-4776
Number of pages9
JournalMedical physics
Issue number9
StatePublished - Sep 2010


  • ADC map
  • diffusion-weighted imaging
  • high intensity focused ultrasound surgery
  • leiomyoma
  • leiomyomata
  • thermotherapy
  • uterine fibroids

ASJC Scopus subject areas

  • Biophysics
  • Radiology Nuclear Medicine and imaging


Dive into the research topics of 'Comparison between diffusion-weighted imaging, T<sub>1</sub>-weighted, and postcontrast T<sub>1</sub>-weighted imaging after MR-guided, high intensity, focused ultrasound treatment of uterine leiomyomata: Preliminary results'. Together they form a unique fingerprint.

Cite this