The Limulus amoebocyte lysate (LAL) test has replaced about 80% of the use of the rabbit pyrogen test. Ideally, human-based in vitro tests are needed, to replace the remaining use of the rabbit test and the use of the LAL test. The progress of an EU-funded project is described, in which a number of in vitro tests based on the human fever reaction are passing through a prevalidation study on the way to evaluation in a formal validation study.
- Human fever reaction
- In vitro pyrogen tests
- LAL test
- Rabbit pyrogen test
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)
- Medical Laboratory Technology