Comparison and validation of novel pyrogen tests based on the human fever reaction

Thomas Hartung, S. Poole, T. Montag-Lessing, R. Nibbeling, G. Werner-Felmayer, T. Jungi, P. Brügger, S. Coecke, I. Aaberge, S. Berthold

Research output: Contribution to journalArticlepeer-review

Abstract

The Limulus amoebocyte lysate (LAL) test has replaced about 80% of the use of the rabbit pyrogen test. Ideally, human-based in vitro tests are needed, to replace the remaining use of the rabbit test and the use of the LAL test. The progress of an EU-funded project is described, in which a number of in vitro tests based on the human fever reaction are passing through a prevalidation study on the way to evaluation in a formal validation study.

Original languageEnglish (US)
Pages (from-to)49-51
Number of pages3
JournalATLA Alternatives to Laboratory Animals
Volume30
Issue numberSUPPL. 2
DOIs
StatePublished - Dec 2002
Externally publishedYes

Keywords

  • Human fever reaction
  • In vitro pyrogen tests
  • LAL test
  • Prevalidation
  • Pyrogens
  • Rabbit pyrogen test
  • Validation

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Toxicology
  • Medical Laboratory Technology

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