Comparing the understanding of subjects receiving a candidate malaria vaccine in the United States and Mali

Ruth D. Ellis, Issaka Sagara, Anna Durbin, Alassane Dicko, Donna Shaffer, Louis Miller, Mahamadoun H. Assadou, Mamady Kone, Beh Kamate, Ousmane Guindo, Michael P. Fay, Dapa A. Diallo, Ogobara K. Doumbo, Ezekiel J. Emanuel, Joseph Millum

Research output: Contribution to journalArticlepeer-review


Initial responses to questionnaires used to assess participants' understanding of informed consent for malaria vaccine trials conducted in the United States and Mali were tallied. Total scores were analyzed by age, sex, literacy (if known), and location. Ninety-two percent (92%) of answers by United States participants and 85% of answers by Malian participants were correct. Questions more likely to be answered incorrectly in Mali related to risk, and to the type of vaccine. For adult participants, independent predictors of higher scores were younger age and female sex in the United States, and male sex in Mali. Scores in the United States were higher than in Mali (P = 0.005). Despite this difference participants at both sites were well informed overall. Although interpretation must be qualified because questionnaires were not intended as research tools and were not standardized among sites, these results do not support concerns about systematic low understanding among research participants in developing versus developed countries.

Original languageEnglish (US)
Pages (from-to)868-872
Number of pages5
JournalAmerican Journal of Tropical Medicine and Hygiene
Issue number4
StatePublished - Oct 2010

ASJC Scopus subject areas

  • Parasitology
  • Virology
  • Infectious Diseases


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