Comparing inhaled ultrafine versus fine zinc oxide particles in healthy adults: A human inhalation study

William S. Beckett, David F. Chalupa, Andrea Pauly-Brown, Donna M. Speers, Judith C. Stewart, Mark W. Frampton, Mark J. Utell, Li Shan Huang, Christopher Cox, Wojciech Zareba, Günter Oberdörster

Research output: Contribution to journalArticle

Abstract

Rationale: Zinc oxide is a common, biologically active constituent of particulate air pollution as well as a workplace toxin. Ultrafine particles (<0.1 μm diameter) are believed to be more potent than an equal mass of inhaled accumulation mode particles (0.1-1.0 μm diameter). Objectives: We compared exposure-response relationships for respiratory, hematologic, and cardiovascular endpoints between ultrafine and accumulation mode zinc oxide particles. Methods: In a human inhalation study, 12 healthy adults inhaled 500 μg/m3 of ultrafine zinc oxide, the same mass of fine zinc oxide, and filtered air while at rest for 2 hours. Measurements and Main Results: Preexposure and follow-up studies of symptoms, leukocyte surface markers, hemostasis, and cardiac electrophysiology were conducted to 24 hours post-exposure. Induced sputum was sampled 24 hours after exposure. No differences were detected between any of the three exposure conditions at this level of exposure. Conclusions: Freshly generated zinc oxide in the fine or ultrafine fractions inhaled by healthy subjects at rest at a concentration of 500 μg/m3 for 2 hours is below the threshold for acute systemic effects as detected by these endpoints.

Original languageEnglish (US)
Pages (from-to)1129-1135
Number of pages7
JournalAmerican Journal of Respiratory and Critical Care Medicine
Volume171
Issue number10
DOIs
StatePublished - May 15 2005
Externally publishedYes

Fingerprint

Zinc Oxide
Inhalation
Cardiac Electrophysiology
Air Pollution
Hemostasis
Sputum
Workplace
Healthy Volunteers
Leukocytes
Air
Ultrafine

Keywords

  • Air pollution
  • Metal fume fever
  • Particulate matter, ultrafine
  • Zinc

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine

Cite this

Beckett, W. S., Chalupa, D. F., Pauly-Brown, A., Speers, D. M., Stewart, J. C., Frampton, M. W., ... Oberdörster, G. (2005). Comparing inhaled ultrafine versus fine zinc oxide particles in healthy adults: A human inhalation study. American Journal of Respiratory and Critical Care Medicine, 171(10), 1129-1135. https://doi.org/10.1164/rccm.200406-837OC

Comparing inhaled ultrafine versus fine zinc oxide particles in healthy adults : A human inhalation study. / Beckett, William S.; Chalupa, David F.; Pauly-Brown, Andrea; Speers, Donna M.; Stewart, Judith C.; Frampton, Mark W.; Utell, Mark J.; Huang, Li Shan; Cox, Christopher; Zareba, Wojciech; Oberdörster, Günter.

In: American Journal of Respiratory and Critical Care Medicine, Vol. 171, No. 10, 15.05.2005, p. 1129-1135.

Research output: Contribution to journalArticle

Beckett, WS, Chalupa, DF, Pauly-Brown, A, Speers, DM, Stewart, JC, Frampton, MW, Utell, MJ, Huang, LS, Cox, C, Zareba, W & Oberdörster, G 2005, 'Comparing inhaled ultrafine versus fine zinc oxide particles in healthy adults: A human inhalation study', American Journal of Respiratory and Critical Care Medicine, vol. 171, no. 10, pp. 1129-1135. https://doi.org/10.1164/rccm.200406-837OC
Beckett, William S. ; Chalupa, David F. ; Pauly-Brown, Andrea ; Speers, Donna M. ; Stewart, Judith C. ; Frampton, Mark W. ; Utell, Mark J. ; Huang, Li Shan ; Cox, Christopher ; Zareba, Wojciech ; Oberdörster, Günter. / Comparing inhaled ultrafine versus fine zinc oxide particles in healthy adults : A human inhalation study. In: American Journal of Respiratory and Critical Care Medicine. 2005 ; Vol. 171, No. 10. pp. 1129-1135.
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