Abstract
Rationale: Zinc oxide is a common, biologically active constituent of particulate air pollution as well as a workplace toxin. Ultrafine particles (< 0.1 μm diameter) are believed to be more potent than an equal mass of inhaled accumulation mode particles (0.1-1.0 μm diameter). Objectives: We compared exposure-response relationships for respiratory, hematologic, and cardiovascular endpoints between ultrafine and accumulation mode zinc oxide particles. Methods: In a human inhalation study, 12 healthy adults inhaled 500 μg/m3 of ultrafine zinc oxide, the same mass of fine zinc oxide, and filtered air while at rest for 2 hours. Measurements and Main Results: Preexposure and follow-up studies of symptoms, leukocyte surface markers, hemostasis, and cardiac electrophysiology were conducted to 24 hours post-exposure. Induced sputum was sampled 24 hours after exposure. No differences were detected between any of the three exposure conditions at this level of exposure. Conclusions: Freshly generated zinc oxide in the fine or ultrafine fractions inhaled by healthy subjects at rest at a concentration of 500 μg/m3 for 2 hours is below the threshold for acute systemic effects as detected by these endpoints.
Original language | English (US) |
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Pages (from-to) | 1129-1135 |
Number of pages | 7 |
Journal | American journal of respiratory and critical care medicine |
Volume | 171 |
Issue number | 10 |
DOIs | |
State | Published - May 15 2005 |
Externally published | Yes |
Keywords
- Air pollution
- Metal fume fever
- Particulate matter, ultrafine
- Zinc
ASJC Scopus subject areas
- Pulmonary and Respiratory Medicine
- Critical Care and Intensive Care Medicine