Comparing encounter-based and annualized chronic pseudomonas infection definitions in cystic fibrosis

Margaret Rosenfeld, Anna V. Faino, Frankline Onchiri, Melis A. Aksit, Scott M. Blackman, Elizabeth E. Blue, Joseph M. Collaco, William W. Gordon, Rhonda G. Pace, Karen S. Raraigh, Yi Hui Zhou, Garry R. Cutting, Michael R. Knowles, Michael J. Bamshad, Ronald L. Gibson

Research output: Contribution to journalArticlepeer-review

Abstract

Chronic Pseudomonas aeruginosa (Pa) infection is associated with increased morbidity and mortality in people with cystic fibrosis (CF). There is no gold standard definition of chronic Pa infection in CF. We compared chronic Pa definitions using encounter-based versus annualized data in the Early Pseudomonas Infection Control (EPIC) Observational study cohort, and subsequently compared annualized chronic Pa definitions across a range of U.S. cohorts spanning decades of CF care. We found that an annualized chronic Pa definition requiring at least 1 Pa+ culture in 3 of 4 consecutive years (“Green 3/4”) resulted in chronic Pa metrics similar to established encounter-based modified Leeds criteria definitions, including a similar age at and proportion who fulfilled chronic Pa criteria, and a similar proportion with sustained Pa infection after meeting the chronic Pa definition. The Green 3/4 chronic Pa definition will be valuable for longitudinal analyses in cohorts with limited culture frequency.

Original languageEnglish (US)
JournalJournal of Cystic Fibrosis
DOIs
StateAccepted/In press - 2021

Keywords

  • Pseudomonas aeruginosa
  • chronic infection
  • cystic fibrosis
  • definitions

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Pulmonary and Respiratory Medicine

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