Comparing encounter-based and annualized chronic pseudomonas infection definitions in cystic fibrosis

Margaret Rosenfeld; Anna V. Faino; Frankline Onchiri; Melis A. Aksit; Scott M. Blackman; Elizabeth E. Blue; Joseph M. Collaco; William W. Gordon; Rhonda G. Pace; Karen S. Raraigh; Yi Hui Zhou; Garry R. Cutting; Michael R. Knowles; Michael J. Bamshad; Ronald L. Gibson

doi:10.1016/j.jcf.2021.07.020

Comparing encounter-based and annualized chronic pseudomonas infection definitions in cystic fibrosis

Margaret Rosenfeld, Anna V. Faino, Frankline Onchiri, Melis A. Aksit, Scott M. Blackman, Elizabeth E. Blue, Joseph M. Collaco, William W. Gordon, Rhonda G. Pace, Karen S. Raraigh, Yi Hui Zhou, Garry R. Cutting, Michael R. Knowles, Michael J. Bamshad, Ronald L. Gibson

School of Medicine

Research output: Contribution to journal › Article › peer-review

Abstract

Chronic Pseudomonas aeruginosa (Pa) infection is associated with increased morbidity and mortality in people with cystic fibrosis (CF). There is no gold standard definition of chronic Pa infection in CF. We compared chronic Pa definitions using encounter-based versus annualized data in the Early Pseudomonas Infection Control (EPIC) Observational study cohort, and subsequently compared annualized chronic Pa definitions across a range of U.S. cohorts spanning decades of CF care. We found that an annualized chronic Pa definition requiring at least 1 Pa+ culture in 3 of 4 consecutive years (“Green 3/4”) resulted in chronic Pa metrics similar to established encounter-based modified Leeds criteria definitions, including a similar age at and proportion who fulfilled chronic Pa criteria, and a similar proportion with sustained Pa infection after meeting the chronic Pa definition. The Green 3/4 chronic Pa definition will be valuable for longitudinal analyses in cohorts with limited culture frequency.

Original language	English (US)
Pages (from-to)	40-44
Number of pages	5
Journal	Journal of Cystic Fibrosis
Volume	21
Issue number	1
DOIs	https://doi.org/10.1016/j.jcf.2021.07.020
State	Published - Jan 2022

Keywords

Pseudomonas aeruginosa
chronic infection
cystic fibrosis
definitions

ASJC Scopus subject areas

Pediatrics, Perinatology, and Child Health
Pulmonary and Respiratory Medicine

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10.1016/j.jcf.2021.07.020

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Rosenfeld, M., Faino, A. V., Onchiri, F., Aksit, M. A., Blackman, S. M., Blue, E. E., Collaco, J. M., Gordon, W. W., Pace, R. G., Raraigh, K. S., Zhou, Y. H., Cutting, G. R., Knowles, M. R., Bamshad, M. J., & Gibson, R. L. (2022). Comparing encounter-based and annualized chronic pseudomonas infection definitions in cystic fibrosis. Journal of Cystic Fibrosis, 21(1), 40-44. https://doi.org/10.1016/j.jcf.2021.07.020

Rosenfeld, M, Faino, AV, Onchiri, F, Aksit, MA, Blackman, SM, Blue, EE, Collaco, JM, Gordon, WW, Pace, RG, Raraigh, KS, Zhou, YH, Cutting, GR, Knowles, MR, Bamshad, MJ & Gibson, RL 2022, 'Comparing encounter-based and annualized chronic pseudomonas infection definitions in cystic fibrosis', Journal of Cystic Fibrosis, vol. 21, no. 1, pp. 40-44. https://doi.org/10.1016/j.jcf.2021.07.020

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abstract = "Chronic Pseudomonas aeruginosa (Pa) infection is associated with increased morbidity and mortality in people with cystic fibrosis (CF). There is no gold standard definition of chronic Pa infection in CF. We compared chronic Pa definitions using encounter-based versus annualized data in the Early Pseudomonas Infection Control (EPIC) Observational study cohort, and subsequently compared annualized chronic Pa definitions across a range of U.S. cohorts spanning decades of CF care. We found that an annualized chronic Pa definition requiring at least 1 Pa+ culture in 3 of 4 consecutive years (“Green 3/4”) resulted in chronic Pa metrics similar to established encounter-based modified Leeds criteria definitions, including a similar age at and proportion who fulfilled chronic Pa criteria, and a similar proportion with sustained Pa infection after meeting the chronic Pa definition. The Green 3/4 chronic Pa definition will be valuable for longitudinal analyses in cohorts with limited culture frequency.",

keywords = "Pseudomonas aeruginosa, chronic infection, cystic fibrosis, definitions",

author = "Margaret Rosenfeld and Faino, {Anna V.} and Frankline Onchiri and Aksit, {Melis A.} and Blackman, {Scott M.} and Blue, {Elizabeth E.} and Collaco, {Joseph M.} and Gordon, {William W.} and Pace, {Rhonda G.} and Raraigh, {Karen S.} and Zhou, {Yi Hui} and Cutting, {Garry R.} and Knowles, {Michael R.} and Bamshad, {Michael J.} and Gibson, {Ronald L.}",

note = "Funding Information: This work was supported by CFF (CUTTIN18XX1, BAMSHA18XX0, and KNOWLE18XX0) Funding Information: The authors would like to thank the Cystic Fibrosis Foundation for the use of CF Foundation Patient Registry data to conduct this study. Additionally, we would like to thank the patients, care providers, and clinic coordinators at CF Centers throughout the United States for their contributions to the CF Foundation Patient Registry. All authors confirm that they have no conflicts of interest relevant to this work This work was supported by CFF (CUTTIN18XX1, BAMSHA18XX0, and KNOWLE18XX0) Publisher Copyright: {\textcopyright} 2021",

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AU - Blackman, Scott M.

AU - Blue, Elizabeth E.

AU - Collaco, Joseph M.

AU - Gordon, William W.

AU - Pace, Rhonda G.

AU - Raraigh, Karen S.

AU - Zhou, Yi Hui

AU - Cutting, Garry R.

AU - Knowles, Michael R.

AU - Bamshad, Michael J.

AU - Gibson, Ronald L.

N1 - Funding Information: This work was supported by CFF (CUTTIN18XX1, BAMSHA18XX0, and KNOWLE18XX0) Funding Information: The authors would like to thank the Cystic Fibrosis Foundation for the use of CF Foundation Patient Registry data to conduct this study. Additionally, we would like to thank the patients, care providers, and clinic coordinators at CF Centers throughout the United States for their contributions to the CF Foundation Patient Registry. All authors confirm that they have no conflicts of interest relevant to this work This work was supported by CFF (CUTTIN18XX1, BAMSHA18XX0, and KNOWLE18XX0) Publisher Copyright: © 2021

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N2 - Chronic Pseudomonas aeruginosa (Pa) infection is associated with increased morbidity and mortality in people with cystic fibrosis (CF). There is no gold standard definition of chronic Pa infection in CF. We compared chronic Pa definitions using encounter-based versus annualized data in the Early Pseudomonas Infection Control (EPIC) Observational study cohort, and subsequently compared annualized chronic Pa definitions across a range of U.S. cohorts spanning decades of CF care. We found that an annualized chronic Pa definition requiring at least 1 Pa+ culture in 3 of 4 consecutive years (“Green 3/4”) resulted in chronic Pa metrics similar to established encounter-based modified Leeds criteria definitions, including a similar age at and proportion who fulfilled chronic Pa criteria, and a similar proportion with sustained Pa infection after meeting the chronic Pa definition. The Green 3/4 chronic Pa definition will be valuable for longitudinal analyses in cohorts with limited culture frequency.

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Comparing encounter-based and annualized chronic pseudomonas infection definitions in cystic fibrosis

Abstract

Keywords

ASJC Scopus subject areas

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