Comparing approaches to screening for angle closure in older Chinese adults

J. Andrews, D. S. Chang, Y. Jiang, M. He, P. J. Foster, Beatriz Munoz, K. Kashiwagi, David S Friedman

Research output: Contribution to journalArticle

Abstract

AimsPrimary angle-closure glaucoma is expected to account for nearly 50% of bilateral glaucoma blindness by 2020. This study was conducted to assess the performance of the scanning peripheral anterior chamber depth analyzer (SPAC) and limbal anterior chamber depth (LACD) as screening methods for angle closure.MethodsThis study assessed two clinical populations to compare SPAC, LACD, and gonioscopy: the Zhongshan Angle-closure Prevention Trial, from which 370 patients were eligible as closed-angle participants and the Liwan Eye Study, from which 72 patients were selected as open-angle controls. Eligible participants were assessed by SPAC, LACD, and gonioscopy.ResultsAngle status was defined by gonioscopy. Area under the receiver operating characteristic curve (AUROC) for SPAC was 0.92 (0.89-0.95) whereas AUROC for LACD was 0.94 (0.92-0.97). Using conventional cutoff points, sensitivity/specificity was 93.0%/70.8% for SPAC and 94.1%/87.5% for LACD. Sequential testing using both SPAC and LACD increased the specificity to 94.4% and decreased the sensitivity to 87.0%.ConclusionSPAC has significantly lower specificity than LACD measurement using conventional cutoffs but interpretation of the findings can be performed by modestly trained personnel.

Original languageEnglish (US)
Pages (from-to)96-100
Number of pages5
JournalEye (London, England)
Volume26
Issue number1
DOIs
StatePublished - Jan 2012

Fingerprint

Anterior Chamber
Gonioscopy
ROC Curve
Angle Closure Glaucoma
Blindness
Glaucoma

Keywords

  • angle closure
  • diagnostic techniques
  • glaucoma
  • gonioscopy
  • ophthalmological

ASJC Scopus subject areas

  • Ophthalmology

Cite this

Comparing approaches to screening for angle closure in older Chinese adults. / Andrews, J.; Chang, D. S.; Jiang, Y.; He, M.; Foster, P. J.; Munoz, Beatriz; Kashiwagi, K.; Friedman, David S.

In: Eye (London, England), Vol. 26, No. 1, 01.2012, p. 96-100.

Research output: Contribution to journalArticle

Andrews, J, Chang, DS, Jiang, Y, He, M, Foster, PJ, Munoz, B, Kashiwagi, K & Friedman, DS 2012, 'Comparing approaches to screening for angle closure in older Chinese adults', Eye (London, England), vol. 26, no. 1, pp. 96-100. https://doi.org/10.1038/eye.2011.244
Andrews, J. ; Chang, D. S. ; Jiang, Y. ; He, M. ; Foster, P. J. ; Munoz, Beatriz ; Kashiwagi, K. ; Friedman, David S. / Comparing approaches to screening for angle closure in older Chinese adults. In: Eye (London, England). 2012 ; Vol. 26, No. 1. pp. 96-100.
@article{dd5cf6c4fce041988c58fb68af0fa033,
title = "Comparing approaches to screening for angle closure in older Chinese adults",
abstract = "AimsPrimary angle-closure glaucoma is expected to account for nearly 50{\%} of bilateral glaucoma blindness by 2020. This study was conducted to assess the performance of the scanning peripheral anterior chamber depth analyzer (SPAC) and limbal anterior chamber depth (LACD) as screening methods for angle closure.MethodsThis study assessed two clinical populations to compare SPAC, LACD, and gonioscopy: the Zhongshan Angle-closure Prevention Trial, from which 370 patients were eligible as closed-angle participants and the Liwan Eye Study, from which 72 patients were selected as open-angle controls. Eligible participants were assessed by SPAC, LACD, and gonioscopy.ResultsAngle status was defined by gonioscopy. Area under the receiver operating characteristic curve (AUROC) for SPAC was 0.92 (0.89-0.95) whereas AUROC for LACD was 0.94 (0.92-0.97). Using conventional cutoff points, sensitivity/specificity was 93.0{\%}/70.8{\%} for SPAC and 94.1{\%}/87.5{\%} for LACD. Sequential testing using both SPAC and LACD increased the specificity to 94.4{\%} and decreased the sensitivity to 87.0{\%}.ConclusionSPAC has significantly lower specificity than LACD measurement using conventional cutoffs but interpretation of the findings can be performed by modestly trained personnel.",
keywords = "angle closure, diagnostic techniques, glaucoma, gonioscopy, ophthalmological",
author = "J. Andrews and Chang, {D. S.} and Y. Jiang and M. He and Foster, {P. J.} and Beatriz Munoz and K. Kashiwagi and Friedman, {David S}",
year = "2012",
month = "1",
doi = "10.1038/eye.2011.244",
language = "English (US)",
volume = "26",
pages = "96--100",
journal = "Eye",
issn = "0950-222X",
publisher = "Nature Publishing Group",
number = "1",

}

TY - JOUR

T1 - Comparing approaches to screening for angle closure in older Chinese adults

AU - Andrews, J.

AU - Chang, D. S.

AU - Jiang, Y.

AU - He, M.

AU - Foster, P. J.

AU - Munoz, Beatriz

AU - Kashiwagi, K.

AU - Friedman, David S

PY - 2012/1

Y1 - 2012/1

N2 - AimsPrimary angle-closure glaucoma is expected to account for nearly 50% of bilateral glaucoma blindness by 2020. This study was conducted to assess the performance of the scanning peripheral anterior chamber depth analyzer (SPAC) and limbal anterior chamber depth (LACD) as screening methods for angle closure.MethodsThis study assessed two clinical populations to compare SPAC, LACD, and gonioscopy: the Zhongshan Angle-closure Prevention Trial, from which 370 patients were eligible as closed-angle participants and the Liwan Eye Study, from which 72 patients were selected as open-angle controls. Eligible participants were assessed by SPAC, LACD, and gonioscopy.ResultsAngle status was defined by gonioscopy. Area under the receiver operating characteristic curve (AUROC) for SPAC was 0.92 (0.89-0.95) whereas AUROC for LACD was 0.94 (0.92-0.97). Using conventional cutoff points, sensitivity/specificity was 93.0%/70.8% for SPAC and 94.1%/87.5% for LACD. Sequential testing using both SPAC and LACD increased the specificity to 94.4% and decreased the sensitivity to 87.0%.ConclusionSPAC has significantly lower specificity than LACD measurement using conventional cutoffs but interpretation of the findings can be performed by modestly trained personnel.

AB - AimsPrimary angle-closure glaucoma is expected to account for nearly 50% of bilateral glaucoma blindness by 2020. This study was conducted to assess the performance of the scanning peripheral anterior chamber depth analyzer (SPAC) and limbal anterior chamber depth (LACD) as screening methods for angle closure.MethodsThis study assessed two clinical populations to compare SPAC, LACD, and gonioscopy: the Zhongshan Angle-closure Prevention Trial, from which 370 patients were eligible as closed-angle participants and the Liwan Eye Study, from which 72 patients were selected as open-angle controls. Eligible participants were assessed by SPAC, LACD, and gonioscopy.ResultsAngle status was defined by gonioscopy. Area under the receiver operating characteristic curve (AUROC) for SPAC was 0.92 (0.89-0.95) whereas AUROC for LACD was 0.94 (0.92-0.97). Using conventional cutoff points, sensitivity/specificity was 93.0%/70.8% for SPAC and 94.1%/87.5% for LACD. Sequential testing using both SPAC and LACD increased the specificity to 94.4% and decreased the sensitivity to 87.0%.ConclusionSPAC has significantly lower specificity than LACD measurement using conventional cutoffs but interpretation of the findings can be performed by modestly trained personnel.

KW - angle closure

KW - diagnostic techniques

KW - glaucoma

KW - gonioscopy

KW - ophthalmological

UR - http://www.scopus.com/inward/record.url?scp=84862951239&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84862951239&partnerID=8YFLogxK

U2 - 10.1038/eye.2011.244

DO - 10.1038/eye.2011.244

M3 - Article

C2 - 21997356

AN - SCOPUS:84862951239

VL - 26

SP - 96

EP - 100

JO - Eye

JF - Eye

SN - 0950-222X

IS - 1

ER -