Comparative typing of human kidney cells and lymphocytes by immune adherence

Bernard DePlanque; Melville G. Williams; Alice Siegel; Carol Alvarez

doi:10.1097/00007890-196912000-00012

Comparative typing of human kidney cells and lymphocytes by immune adherence

Bernard DePlanque, Melville G. Williams, Alice Siegel, Carol Alvarez

School of Medicine

Research output: Contribution to journal › Article › peer-review

12 Scopus citations

Abstract

The immune adherence technique was modified to permit a direct comparison between the reactivity of lymphocytes and kidney cells from the same person. These two cells were typed using 17 well characterized antisera. There were 82 significant discrepancies from a total of 234 direct comparisons. Absorptions with the negatively reacting cell resulted in diminished or absent serological activity against the positive cell type. The results support the concept that significant quantitative differences in the expression of isoantigens exist among different cell types.

Original language	English (US)
Pages (from-to)	852-860
Number of pages	9
Journal	Transplantation
Volume	8
Issue number	6
DOIs	https://doi.org/10.1097/00007890-196912000-00012
State	Published - Dec 1969

ASJC Scopus subject areas

Transplantation

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10.1097/00007890-196912000-00012

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abstract = "The immune adherence technique was modified to permit a direct comparison between the reactivity of lymphocytes and kidney cells from the same person. These two cells were typed using 17 well characterized antisera. There were 82 significant discrepancies from a total of 234 direct comparisons. Absorptions with the negatively reacting cell resulted in diminished or absent serological activity against the positive cell type. The results support the concept that significant quantitative differences in the expression of isoantigens exist among different cell types.",

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AB - The immune adherence technique was modified to permit a direct comparison between the reactivity of lymphocytes and kidney cells from the same person. These two cells were typed using 17 well characterized antisera. There were 82 significant discrepancies from a total of 234 direct comparisons. Absorptions with the negatively reacting cell resulted in diminished or absent serological activity against the positive cell type. The results support the concept that significant quantitative differences in the expression of isoantigens exist among different cell types.

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Comparative typing of human kidney cells and lymphocytes by immune adherence

Abstract

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