We performed a prospective randomized study to evaluate the effectiveness and safety of once-daily administrations of fleroxacin (FLRX) for the treatment of complicated urinary tract infections. A comparative study was conducted with administration of 200mg FLRX once a day, after breakfast or after dinner, for 7 days. Of a total 167 cases, 62 cases in the morning-administration group and 61 cases in the evening-administration group were evaluated under the criteria proposed by the Japanese UTI committee. The overall clinical efficacy was 67.7% in the morning group and 55.7% in the evening group. No significant difference was revealed between these two groups. Clinical adverse reactions were recognized in 3 cases in the morning group (85 cases) and 1 case in the evening group (80 cases). Abnormal laboratory findings were found in one case in the morning group. As a result, there were no significant differences in the effectiveness and safety of FLRX, regardless of the timing of administration. It was suggested that the timing of the administration of FLRX can be arranged to fit in with the lifestyle of the patients and the drug shows good compliance.
|Original language||English (US)|
|Number of pages||12|
|Journal||Nishinihon Journal of Urology|
|State||Published - 1998|
- Complicated urinary tract infection
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