TY - JOUR
T1 - Comparative studies of viral infections of the developing forebrain
T2 - I. Pathogenesis of rat virus and bluetongue vaccine virus infections in neonatal hamsters
AU - Becker, Laurence E.
AU - Narayan, Opendra
AU - Johnson, Richard T.
PY - 1974/8
Y1 - 1974/8
N2 - The pathogenesis of rat virus and bluetongue vaccine virus (BTW) infections were studied in the forebrains of newborn hamsters. Both infections were initially confined to cells of the subventricular zone (SVZ) and comparable amounts of infectious virus were replicated, yet these infections led to different sequelae. BTW infection eventually spread outward from the SVZ to the cortex, dentate gyrus and internal granule cells of the olfactory bulbs. Bat virus infection remained confined to the SVZ. BTW infection produced an intense inflammatory response, whereas rat virus infection evoked almost no inflammation. Based on the maturational changes in the germinal cells of the forebrain and on the different biological properties of the two viruses, the reasons for the contrasting effects of these viruses on the forebrain are discussed.
AB - The pathogenesis of rat virus and bluetongue vaccine virus (BTW) infections were studied in the forebrains of newborn hamsters. Both infections were initially confined to cells of the subventricular zone (SVZ) and comparable amounts of infectious virus were replicated, yet these infections led to different sequelae. BTW infection eventually spread outward from the SVZ to the cortex, dentate gyrus and internal granule cells of the olfactory bulbs. Bat virus infection remained confined to the SVZ. BTW infection produced an intense inflammatory response, whereas rat virus infection evoked almost no inflammation. Based on the maturational changes in the germinal cells of the forebrain and on the different biological properties of the two viruses, the reasons for the contrasting effects of these viruses on the forebrain are discussed.
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U2 - 10.1097/00005072-197408000-00003
DO - 10.1097/00005072-197408000-00003
M3 - Article
C2 - 4370665
AN - SCOPUS:0016293490
SN - 0022-3069
VL - 33
SP - 519
EP - 529
JO - Journal of neuropathology and experimental neurology
JF - Journal of neuropathology and experimental neurology
IS - 4
ER -