Comparative Properties of Five Human Ovarian Adenocarcinoma Cell Lines

R. N. Buick, R. Pullano, J. M. Trent

Research output: Contribution to journalArticlepeer-review

287 Scopus citations

Abstract

We describe the derivation of three human ovarian carcinoma cell lines and the comparison of their properties with two previously described cell lines of like histology (SKOV-3 and CAOV-3). Two of the new lines (HOC-1 and HOC-7) were derived from separate ascites tumors (at 9-month intervals) of a patient with well-differentiated serous adenocarcinoma of the ovary. The third new line, HEY, was derived from a human ovarian cancer xenograft (HX-62) originally grown from a peritoneal deposit of a patient with moderately differentiated papillary cystadenocarcinoma of the ovary. The cell lines demonstrated differential ability to grow in semisolid culture and as xenografts in immunologically deprived CBA/CJ mice. Dose-response curves were generated for clonogenic cell survival of cells exposed to common chemotherapeutic agents; one of the lines (HEY) shows a degree of resistance to the alkylating agent c/s-diamminedichloroplati-num(ll) (c/s-platinum). Common karyological features included structural abnormalities of chromosomes 3 and 11. Heterogeneity of expression of ovarian tumor-associated antigens was documented.

Original languageEnglish (US)
Pages (from-to)3668-3676
Number of pages9
JournalCancer Research
Volume45
Issue number8
StatePublished - Aug 1 1985

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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