Melatonin and its benzo[b]thiophene analog were labeled by acetylation of the corresponding 5-methoxyarylethylamines with 3H-acetic anhydride. The benzo[b]thiophene analog had a much higher lipid solubility. When administered to rats, both compounds disappeared from plasma and tissues by first-order decay. The dispositions were similar, with the higher lipid solubility of the benzo[b]thiophene analog resulting in higher tissue: plasma ratios, especially in adipose tissue, kidney and liver, and longer half-lives in plasma and tissues.
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)
- Pharmacology, Toxicology and Pharmaceutics(all)