Comparative physiological disposition of melatonin and its benzo[b]thiophene analog in the rat

Roger P. Maickel, Talmage R. Bosin, Steadman D. Harrison, Mark A. Riddle

Research output: Contribution to journalArticlepeer-review

Abstract

Melatonin and its benzo[b]thiophene analog were labeled by acetylation of the corresponding 5-methoxyarylethylamines with 3H-acetic anhydride. The benzo[b]thiophene analog had a much higher lipid solubility. When administered to rats, both compounds disappeared from plasma and tissues by first-order decay. The dispositions were similar, with the higher lipid solubility of the benzo[b]thiophene analog resulting in higher tissue: plasma ratios, especially in adipose tissue, kidney and liver, and longer half-lives in plasma and tissues.

Original languageEnglish (US)
Pages (from-to)1735-1739
Number of pages5
JournalLife Sciences
Volume14
Issue number9
DOIs
StatePublished - May 1 1974
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Pharmacology, Toxicology and Pharmaceutics(all)

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