TY - JOUR
T1 - Comparative Outcomes in Children and Adults with Anti- N -Methyl-D-Aspartate (anti-NMDA) Receptor Encephalitis
AU - Gordon-Lipkin, Eliza
AU - Yeshokumar, Anusha K.
AU - Saylor, Deanna
AU - Arenivas, Ana
AU - Probasco, John C.
N1 - Funding Information:
The authors disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: This project was supported by Johns Hopkins Center for Refractory Status Epilepticus and Neuroinflammation and the Johns Hopkins Encephalitis Center.
Publisher Copyright:
© 2017 Author(s).
PY - 2017/10/1
Y1 - 2017/10/1
N2 - This study compared neurologic disability and adaptive function in children and adults >1 year following anti-N-methyl-d-aspartate receptor (anti-NMDAR) encephalitis diagnosis. Retrospective record review identified 12 patients with anti-NMDAR encephalitis. At last follow-up, all surviving patients had "good" modified Rankin Score (0-2). Four children, 6 adults, and their families participated in a telephone interview. Median duration since diagnosis was similar for children (2.42 years, interquartile range 2.12-3.32) and adults (3.55 years, interquartile range 2.08-5.50 years). 3/4 (75%) pediatric and 3/5 (60%) adult patients reported neuropsychiatric symptoms (fatigue, emotional lability, short-term memory deficits or concentration deficits). On the Adaptive Behavior Assessment System (ABAS-3), although overall adaptive function was intact for adults (general adaptive composite standard score: median 104.5, interquartile range 98.8-112.5), the median for children was below average (General Adaptive Composite Standard Score: median 82.0, interquartile range 79.0-89.0). Children with anti-NDMAR encephalitis may have long-term effects impacting daily life while adults regain normal function.
AB - This study compared neurologic disability and adaptive function in children and adults >1 year following anti-N-methyl-d-aspartate receptor (anti-NMDAR) encephalitis diagnosis. Retrospective record review identified 12 patients with anti-NMDAR encephalitis. At last follow-up, all surviving patients had "good" modified Rankin Score (0-2). Four children, 6 adults, and their families participated in a telephone interview. Median duration since diagnosis was similar for children (2.42 years, interquartile range 2.12-3.32) and adults (3.55 years, interquartile range 2.08-5.50 years). 3/4 (75%) pediatric and 3/5 (60%) adult patients reported neuropsychiatric symptoms (fatigue, emotional lability, short-term memory deficits or concentration deficits). On the Adaptive Behavior Assessment System (ABAS-3), although overall adaptive function was intact for adults (general adaptive composite standard score: median 104.5, interquartile range 98.8-112.5), the median for children was below average (General Adaptive Composite Standard Score: median 82.0, interquartile range 79.0-89.0). Children with anti-NDMAR encephalitis may have long-term effects impacting daily life while adults regain normal function.
KW - NMDA
KW - adaptive
KW - autoimmune
KW - encephalitis
KW - outcome
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U2 - 10.1177/0883073817720340
DO - 10.1177/0883073817720340
M3 - Article
C2 - 28730861
AN - SCOPUS:85029075160
SN - 0883-0738
VL - 32
SP - 930
EP - 935
JO - Journal of child neurology
JF - Journal of child neurology
IS - 11
ER -