Comparative Outcomes in Children and Adults with Anti- N -Methyl-D-Aspartate (anti-NMDA) Receptor Encephalitis

Eliza Gordon-Lipkin, Anusha K. Yeshokumar, Deanna Saylor, Ana Arenivas, John C. Probasco

Research output: Contribution to journalArticle

Abstract

This study compared neurologic disability and adaptive function in children and adults >1 year following anti-N-methyl-d-aspartate receptor (anti-NMDAR) encephalitis diagnosis. Retrospective record review identified 12 patients with anti-NMDAR encephalitis. At last follow-up, all surviving patients had "good" modified Rankin Score (0-2). Four children, 6 adults, and their families participated in a telephone interview. Median duration since diagnosis was similar for children (2.42 years, interquartile range 2.12-3.32) and adults (3.55 years, interquartile range 2.08-5.50 years). 3/4 (75%) pediatric and 3/5 (60%) adult patients reported neuropsychiatric symptoms (fatigue, emotional lability, short-term memory deficits or concentration deficits). On the Adaptive Behavior Assessment System (ABAS-3), although overall adaptive function was intact for adults (general adaptive composite standard score: median 104.5, interquartile range 98.8-112.5), the median for children was below average (General Adaptive Composite Standard Score: median 82.0, interquartile range 79.0-89.0). Children with anti-NDMAR encephalitis may have long-term effects impacting daily life while adults regain normal function.

Original languageEnglish (US)
Pages (from-to)930-935
Number of pages6
JournalJournal of child neurology
Volume32
Issue number11
DOIs
StatePublished - Oct 1 2017

Keywords

  • NMDA
  • adaptive
  • autoimmune
  • encephalitis
  • outcome

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Clinical Neurology

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