Comparative metabolism of hydrocodone in man, rat, guinea pig, rabbit, and dog

E. J. Cone, W. D. Darwin, C. W. Gorodetzky, T. Tan

Research output: Contribution to journalArticle

Abstract

The metabolism of hydrocodone was studied in man, rat, guinea pig, rabbit, and dog. Routes of metabolism included O-demethylation, N-dealkylation, and 6-keto-reduction to the corresponding 6-α- and 6-β-hydroxy metabolites, where each metabolic pathway produces an active metabolite. Mean total recovery of drug and metabolites as percentage of administered dose ranged from a low of 10.6% for the rabbit to a high of 46.8% for the guinea pig; man was intermediate at 25.7%. For man, approximately 70% of the total drug recovered was excreted in the first 24 hr, and the remainder by 72 hr. Considerable species differences were observed in the patients of metabolism of hydrocodone. Also, stereoselectivity of 6-keto reduction to the β-form was observed for all species in the reduction of hydrocodone and hydromorphone with the exception of the reduction of hydrocodone by man.

Original languageEnglish (US)
Pages (from-to)488-493
Number of pages6
JournalDrug Metabolism and Disposition
Volume6
Issue number4
StatePublished - Dec 1 1978

ASJC Scopus subject areas

  • Pharmacology
  • Pharmaceutical Science

Fingerprint Dive into the research topics of 'Comparative metabolism of hydrocodone in man, rat, guinea pig, rabbit, and dog'. Together they form a unique fingerprint.

  • Cite this

    Cone, E. J., Darwin, W. D., Gorodetzky, C. W., & Tan, T. (1978). Comparative metabolism of hydrocodone in man, rat, guinea pig, rabbit, and dog. Drug Metabolism and Disposition, 6(4), 488-493.