Comparative mapping of rat Iddm4 to segments on HSA7 and MMU6

Lars Hornum, Cheryl DeScipio, Helle Markholst, Scott A. Troutman, Stephen Novak, Jean Leif, Dale Greiner, John P. Mordes, Elizabeth P. Blankenhorn

Research output: Contribution to journalArticle

Abstract

Iddm4 is one of several susceptibility genes that have been identified in the BB rat model of type 1 diabetes. The BB rat allele of this gene confers dominant predisposition to diabetes induction by immune perturbation in both the diabetes-prone and the diabetes-resistant substrains, whereas the Wistar Furth (WF) allele confers resistance. We have positioned the gene in a 2.8-cM region on rat Chromosome (Chr) 4, proximal to Lyp/Ian411. We have produced a radiation hybrid map of the Iddm4-region that includes a number of rat genes with their mouse and human orthologs. We present a comparative map of the rat Iddm4 region in rat, human, and mouse, assigning the gene to a 6.3-Mb segment between PTN and ZYX at 7q32 in the human genome, and to a 5.7-Mb segment between Ptn and Zyx in the mouse genome.

Original languageEnglish (US)
Pages (from-to)53-61
Number of pages9
JournalMammalian Genome
Volume15
Issue number1
DOIs
StatePublished - Jan 2004
Externally publishedYes

ASJC Scopus subject areas

  • Genetics

Fingerprint Dive into the research topics of 'Comparative mapping of rat Iddm4 to segments on HSA7 and MMU6'. Together they form a unique fingerprint.

  • Cite this

    Hornum, L., DeScipio, C., Markholst, H., Troutman, S. A., Novak, S., Leif, J., Greiner, D., Mordes, J. P., & Blankenhorn, E. P. (2004). Comparative mapping of rat Iddm4 to segments on HSA7 and MMU6. Mammalian Genome, 15(1), 53-61. https://doi.org/10.1007/s00335-003-3023-z