Comparative lesion sequencing provides insights into tumor evolution

Siân Jones, Wei Dong Chen, Giovanni Parmigiani, Frank Diehl, Niko Beerenwinkel, Tibor Antal, Arne Traulsen, Martin A. Nowak, Christopher Siegel, Victor E Velculescu, Kenneth W Kinzler, Bert Vogelstein, Joseph Willis, Sanford D. Markowitz

Research output: Contribution to journalArticle

Abstract

We show that the times separating the birth of benign, invasive, and metastatic tumor cells can be determined by analysis of the mutations they have in common. When combined with prior clinical observations, these analyses suggest the following general conclusions about colorectal tumorigenesis: (i) It takes ≈17 years for a large benign tumor to evolve into an advanced cancer but

Original languageEnglish (US)
Pages (from-to)4283-4288
Number of pages6
JournalProceedings of the National Academy of Sciences of the United States of America
Volume105
Issue number11
DOIs
StatePublished - Mar 18 2008

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Neoplasms
Carcinogenesis
Parturition
Mutation

Keywords

  • Cancer genetics
  • Colorectal cancer
  • Metastasis
  • Stem cells

ASJC Scopus subject areas

  • Genetics
  • General

Cite this

Jones, S., Chen, W. D., Parmigiani, G., Diehl, F., Beerenwinkel, N., Antal, T., ... Markowitz, S. D. (2008). Comparative lesion sequencing provides insights into tumor evolution. Proceedings of the National Academy of Sciences of the United States of America, 105(11), 4283-4288. https://doi.org/10.1073/pnas.0712345105

Comparative lesion sequencing provides insights into tumor evolution. / Jones, Siân; Chen, Wei Dong; Parmigiani, Giovanni; Diehl, Frank; Beerenwinkel, Niko; Antal, Tibor; Traulsen, Arne; Nowak, Martin A.; Siegel, Christopher; Velculescu, Victor E; Kinzler, Kenneth W; Vogelstein, Bert; Willis, Joseph; Markowitz, Sanford D.

In: Proceedings of the National Academy of Sciences of the United States of America, Vol. 105, No. 11, 18.03.2008, p. 4283-4288.

Research output: Contribution to journalArticle

Jones, S, Chen, WD, Parmigiani, G, Diehl, F, Beerenwinkel, N, Antal, T, Traulsen, A, Nowak, MA, Siegel, C, Velculescu, VE, Kinzler, KW, Vogelstein, B, Willis, J & Markowitz, SD 2008, 'Comparative lesion sequencing provides insights into tumor evolution', Proceedings of the National Academy of Sciences of the United States of America, vol. 105, no. 11, pp. 4283-4288. https://doi.org/10.1073/pnas.0712345105
Jones, Siân ; Chen, Wei Dong ; Parmigiani, Giovanni ; Diehl, Frank ; Beerenwinkel, Niko ; Antal, Tibor ; Traulsen, Arne ; Nowak, Martin A. ; Siegel, Christopher ; Velculescu, Victor E ; Kinzler, Kenneth W ; Vogelstein, Bert ; Willis, Joseph ; Markowitz, Sanford D. / Comparative lesion sequencing provides insights into tumor evolution. In: Proceedings of the National Academy of Sciences of the United States of America. 2008 ; Vol. 105, No. 11. pp. 4283-4288.
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