TY - JOUR
T1 - Comparative immunopeptidomics of humans and their pathogens
AU - Istrail, Sorin
AU - Florea, Liliana
AU - Halldórsson, Bjarni V.
AU - Kohlbacher, Oliver
AU - Schwartz, Russell S.
AU - Yap, Von Bing
AU - Yewdell, Jonathan W.
AU - Hoffman, Stephen L.
PY - 2004/9/7
Y1 - 2004/9/7
N2 - Major histocompatibility complex class I molecules present peptides of 8-10 residues to CD8+ T cells. We used 19 predicted proteomes to determine the influence of CD8+ T cell immune surveillance on protein evolution in humans and microbial pathogens by predicting immunopeptidomes, i.e., sets of class I binding peptides present in proteomes. We find that class I peptide binding specificities (i) have had little, if any, influence on the evolution of immunopeptidomes and (ii) do not take advantage of biases in amino acid distribution in proteins other than the concentration of hydrophobic residues in NH2-terminal leader sequences.
AB - Major histocompatibility complex class I molecules present peptides of 8-10 residues to CD8+ T cells. We used 19 predicted proteomes to determine the influence of CD8+ T cell immune surveillance on protein evolution in humans and microbial pathogens by predicting immunopeptidomes, i.e., sets of class I binding peptides present in proteomes. We find that class I peptide binding specificities (i) have had little, if any, influence on the evolution of immunopeptidomes and (ii) do not take advantage of biases in amino acid distribution in proteins other than the concentration of hydrophobic residues in NH2-terminal leader sequences.
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U2 - 10.1073/pnas.0404740101
DO - 10.1073/pnas.0404740101
M3 - Article
C2 - 15326311
AN - SCOPUS:4444285822
SN - 0027-8424
VL - 101
SP - 13268
EP - 13272
JO - Proceedings of the National Academy of Sciences of the United States of America
JF - Proceedings of the National Academy of Sciences of the United States of America
IS - 36
ER -