Comparative immunogenicity of human immunodeficiency virus particles and corresponding polypeptides in a DNA vaccine

Wataru Akahata, Zhi Yong Yang, Gary J. Nabel

Research output: Contribution to journalArticle


The immunogenicity of a plasmid DNA expression vector encoding both Gag and envelope (Env), which produced human immunodeficiency virus (HIV) type 1 virus-like particles (VLP), was compared to vectors expressing Gag and Env individually, which presented the same gene products as polypeptides. Vaccination with plasmids that generated VLP showed cellular immunity comparable to that of Gag and cell-mediated or humoral responses similar to those of Env as immunization with separate vectors. These data suggest that DNA vaccines encoding separated HIV polypeptides generate immune responses similar to those generated by viral particles.

Original languageEnglish (US)
Pages (from-to)626-631
Number of pages6
JournalJournal of Virology
Issue number1
Publication statusPublished - Jan 2005
Externally publishedYes


ASJC Scopus subject areas

  • Immunology

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