Comparative histomorphological review of rat and human hepatocellular proliferative lesions

Bob Thoolen; Fiebo J.W. ten Kate; Paulus Joannes van Diest; David E. Malarkey; Susan A. Elmore; Robert R. Maronpot

doi:10.1293/tox.25.189

Comparative histomorphological review of rat and human hepatocellular proliferative lesions

Bob Thoolen, Fiebo J.W. ten Kate, Paulus Joannes van Diest, David E. Malarkey, Susan A. Elmore, Robert R. Maronpot

Research output: Contribution to journal › Review article › peer-review

18 Scopus citations

Abstract

In this comparative review, histomorphological features of common nonneoplastic and neoplastic hepatocyte lesions of rats and humans are examined using H&E-stained slides. The morphological similarities and differences of both neoplastic (hepatocellular carcinoma and hepatocellular adenoma) and presumptive preneoplastic lesions (large and small cell change in humans and foci of cellular alteration in rats) are presented and discussed. There are major similarities in the diagnostic features, growth patterns and behavior of both rat and human hepatocellular proliferative lesions and in the process of hepatocarcinogenesis. Further study of presumptive preneoplastic lesions in humans and rats should help to further define their role in progression to hepatocellular neoplasia in both species.

Original language	English (US)
Pages (from-to)	189-199
Number of pages	11
Journal	Journal of Toxicologic Pathology
Volume	25
Issue number	3
DOIs	https://doi.org/10.1293/tox.25.189
State	Published - 2012
Externally published	Yes

Keywords

Foci of cellular alteration
Hepatocellular adenoma
Hepatocellular carcinoma
Large cell change
Liver
Small cell change

ASJC Scopus subject areas

Pathology and Forensic Medicine
Toxicology

Access to Document

10.1293/tox.25.189

Cite this

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abstract = "In this comparative review, histomorphological features of common nonneoplastic and neoplastic hepatocyte lesions of rats and humans are examined using H&E-stained slides. The morphological similarities and differences of both neoplastic (hepatocellular carcinoma and hepatocellular adenoma) and presumptive preneoplastic lesions (large and small cell change in humans and foci of cellular alteration in rats) are presented and discussed. There are major similarities in the diagnostic features, growth patterns and behavior of both rat and human hepatocellular proliferative lesions and in the process of hepatocarcinogenesis. Further study of presumptive preneoplastic lesions in humans and rats should help to further define their role in progression to hepatocellular neoplasia in both species.",

keywords = "Foci of cellular alteration, Hepatocellular adenoma, Hepatocellular carcinoma, Large cell change, Liver, Small cell change",

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AU - Thoolen, Bob

AU - ten Kate, Fiebo J.W.

AU - van Diest, Paulus Joannes

AU - Malarkey, David E.

AU - Elmore, Susan A.

AU - Maronpot, Robert R.

PY - 2012

Y1 - 2012

N2 - In this comparative review, histomorphological features of common nonneoplastic and neoplastic hepatocyte lesions of rats and humans are examined using H&E-stained slides. The morphological similarities and differences of both neoplastic (hepatocellular carcinoma and hepatocellular adenoma) and presumptive preneoplastic lesions (large and small cell change in humans and foci of cellular alteration in rats) are presented and discussed. There are major similarities in the diagnostic features, growth patterns and behavior of both rat and human hepatocellular proliferative lesions and in the process of hepatocarcinogenesis. Further study of presumptive preneoplastic lesions in humans and rats should help to further define their role in progression to hepatocellular neoplasia in both species.

AB - In this comparative review, histomorphological features of common nonneoplastic and neoplastic hepatocyte lesions of rats and humans are examined using H&E-stained slides. The morphological similarities and differences of both neoplastic (hepatocellular carcinoma and hepatocellular adenoma) and presumptive preneoplastic lesions (large and small cell change in humans and foci of cellular alteration in rats) are presented and discussed. There are major similarities in the diagnostic features, growth patterns and behavior of both rat and human hepatocellular proliferative lesions and in the process of hepatocarcinogenesis. Further study of presumptive preneoplastic lesions in humans and rats should help to further define their role in progression to hepatocellular neoplasia in both species.

KW - Foci of cellular alteration

KW - Hepatocellular adenoma

KW - Hepatocellular carcinoma

KW - Large cell change

KW - Liver

KW - Small cell change

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Comparative histomorphological review of rat and human hepatocellular proliferative lesions

Abstract

Keywords

ASJC Scopus subject areas

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