Comparative genomics of trypanosomatid parasitic protozoa

Najib M. El-Sayed; Peter J. Myler; Gaëlle Blandin; Matthew Berriman; Jonathan Crabtree; Gautam Aggarwal; Elisabet Caler; Hubert Renauld; Elizabeth A. Worthey; Christiane Hertz-Fowler; Elodie Ghedin; Christopher Peacock; Daniella C. Bartholomeu; Brian J. Haas; Anh Nhi Tran; Jennifer R. Wortman; U. Cecilia M. Alsmark; Samuel Angiuoli; Atashi Anupama; Jonathan Badger; Frederic Bringaud; Eithon Cadag; Jane M. Carlton; Gustavo C. Cerqueira; Todd Creasy; Arthur L. Delcher; Appolinaire Djikeng; T. Martin Embley; Christopher Hauser; Alasdair C. Ivens; Sarah K. Kummerfeld; Jose B. Pereira-Leal; Daniel Nilsson; Jeremy Peterson; Steven L. Salzberg; Joshua Shallom; Joana C. Silva; Jaideep Sundaram; Scott Westenberger; Owen White; Sara E. Melville; John E. Donelson; Björn Andersson; Kenneth D. Stuart; Neil Hall

doi:10.1126/science.1112181

Comparative genomics of trypanosomatid parasitic protozoa

Najib M. El-Sayed, Peter J. Myler, Gaëlle Blandin, Matthew Berriman, Jonathan Crabtree, Gautam Aggarwal, Elisabet Caler, Hubert Renauld, Elizabeth A. Worthey, Christiane Hertz-Fowler, Elodie Ghedin, Christopher Peacock, Daniella C. Bartholomeu, Brian J. Haas, Anh Nhi Tran, Jennifer R. Wortman, U. Cecilia M. Alsmark, Samuel Angiuoli, Atashi Anupama, Jonathan BadgerFrederic Bringaud, Eithon Cadag, Jane M. Carlton, Gustavo C. Cerqueira, Todd Creasy, Arthur L. Delcher, Appolinaire Djikeng, T. Martin Embley, Christopher Hauser, Alasdair C. Ivens, Sarah K. Kummerfeld, Jose B. Pereira-Leal, Daniel Nilsson, Jeremy Peterson, Steven L. Salzberg, Joshua Shallom, Joana C. Silva, Jaideep Sundaram, Scott Westenberger, Owen White, Sara E. Melville, John E. Donelson, Björn Andersson, Kenneth D. Stuart, Neil Hall

Research output: Contribution to journal › Article › peer-review

566 Scopus citations

Abstract

A comparison of gene content and genome architecture of Trypanosoma brucei, Trypanosoma cruzi, and Leishmania major, three related pathogens with different life cycles and disease pathology, revealed a conserved core proteome of about 6200 genes in large syntenic polycistronic gene clusters. Many species-specific genes, especially large surface antigen families, occur at nonsyntenic chromosome-internal and subtelomeric regions. Retroelements, structural RNAs, and gene family expansion are often associated with syntenic discontinuities that-along with gene divergence, acquisition and loss, and rearrangement within the syntenic regions-have shaped the genomes of each parasite. Contrary to recent reports, our analyses reveal no evidence that these species are descended from an ancestor that contained a photosynthetic endosymbiont.

Original language	English (US)
Pages (from-to)	404-409+435
Journal	Science
Volume	309
Issue number	5733
DOIs	https://doi.org/10.1126/science.1112181
State	Published - Jul 15 2005
Externally published	Yes

ASJC Scopus subject areas

General

Access to Document

10.1126/science.1112181

Cite this

El-Sayed, N. M., Myler, P. J., Blandin, G., Berriman, M., Crabtree, J., Aggarwal, G., Caler, E., Renauld, H., Worthey, E. A., Hertz-Fowler, C., Ghedin, E., Peacock, C., Bartholomeu, D. C., Haas, B. J., Tran, A. N., Wortman, J. R., Alsmark, U. C. M., Angiuoli, S., Anupama, A., ... Hall, N. (2005). Comparative genomics of trypanosomatid parasitic protozoa. Science, 309(5733), 404-409+435. https://doi.org/10.1126/science.1112181

El-Sayed, NM, Myler, PJ, Blandin, G, Berriman, M, Crabtree, J, Aggarwal, G, Caler, E, Renauld, H, Worthey, EA, Hertz-Fowler, C, Ghedin, E, Peacock, C, Bartholomeu, DC, Haas, BJ, Tran, AN, Wortman, JR, Alsmark, UCM, Angiuoli, S, Anupama, A, Badger, J, Bringaud, F, Cadag, E, Carlton, JM, Cerqueira, GC, Creasy, T, Delcher, AL, Djikeng, A, Embley, TM, Hauser, C, Ivens, AC, Kummerfeld, SK, Pereira-Leal, JB, Nilsson, D, Peterson, J, Salzberg, SL, Shallom, J, Silva, JC, Sundaram, J, Westenberger, S, White, O, Melville, SE, Donelson, JE, Andersson, B, Stuart, KD & Hall, N 2005, 'Comparative genomics of trypanosomatid parasitic protozoa', Science, vol. 309, no. 5733, pp. 404-409+435. https://doi.org/10.1126/science.1112181

@article{810bb50dcb1e47b8b24ed87122185c65,

title = "Comparative genomics of trypanosomatid parasitic protozoa",

abstract = "A comparison of gene content and genome architecture of Trypanosoma brucei, Trypanosoma cruzi, and Leishmania major, three related pathogens with different life cycles and disease pathology, revealed a conserved core proteome of about 6200 genes in large syntenic polycistronic gene clusters. Many species-specific genes, especially large surface antigen families, occur at nonsyntenic chromosome-internal and subtelomeric regions. Retroelements, structural RNAs, and gene family expansion are often associated with syntenic discontinuities that-along with gene divergence, acquisition and loss, and rearrangement within the syntenic regions-have shaped the genomes of each parasite. Contrary to recent reports, our analyses reveal no evidence that these species are descended from an ancestor that contained a photosynthetic endosymbiont.",

author = "El-Sayed, {Najib M.} and Myler, {Peter J.} and Ga{\"e}lle Blandin and Matthew Berriman and Jonathan Crabtree and Gautam Aggarwal and Elisabet Caler and Hubert Renauld and Worthey, {Elizabeth A.} and Christiane Hertz-Fowler and Elodie Ghedin and Christopher Peacock and Bartholomeu, {Daniella C.} and Haas, {Brian J.} and Tran, {Anh Nhi} and Wortman, {Jennifer R.} and Alsmark, {U. Cecilia M.} and Samuel Angiuoli and Atashi Anupama and Jonathan Badger and Frederic Bringaud and Eithon Cadag and Carlton, {Jane M.} and Cerqueira, {Gustavo C.} and Todd Creasy and Delcher, {Arthur L.} and Appolinaire Djikeng and Embley, {T. Martin} and Christopher Hauser and Ivens, {Alasdair C.} and Kummerfeld, {Sarah K.} and Pereira-Leal, {Jose B.} and Daniel Nilsson and Jeremy Peterson and Salzberg, {Steven L.} and Joshua Shallom and Silva, {Joana C.} and Jaideep Sundaram and Scott Westenberger and Owen White and Melville, {Sara E.} and Donelson, {John E.} and Bj{\"o}rn Andersson and Stuart, {Kenneth D.} and Neil Hall",

year = "2005",

month = jul,

day = "15",

doi = "10.1126/science.1112181",

language = "English (US)",

volume = "309",

pages = "404--409+435",

journal = "Science",

issn = "0036-8075",

publisher = "American Association for the Advancement of Science",

number = "5733",

}

TY - JOUR

T1 - Comparative genomics of trypanosomatid parasitic protozoa

AU - El-Sayed, Najib M.

AU - Myler, Peter J.

AU - Blandin, Gaëlle

AU - Berriman, Matthew

AU - Crabtree, Jonathan

AU - Aggarwal, Gautam

AU - Caler, Elisabet

AU - Renauld, Hubert

AU - Worthey, Elizabeth A.

AU - Hertz-Fowler, Christiane

AU - Ghedin, Elodie

AU - Peacock, Christopher

AU - Bartholomeu, Daniella C.

AU - Haas, Brian J.

AU - Tran, Anh Nhi

AU - Wortman, Jennifer R.

AU - Alsmark, U. Cecilia M.

AU - Angiuoli, Samuel

AU - Anupama, Atashi

AU - Badger, Jonathan

AU - Bringaud, Frederic

AU - Cadag, Eithon

AU - Carlton, Jane M.

AU - Cerqueira, Gustavo C.

AU - Creasy, Todd

AU - Delcher, Arthur L.

AU - Djikeng, Appolinaire

AU - Embley, T. Martin

AU - Hauser, Christopher

AU - Ivens, Alasdair C.

AU - Kummerfeld, Sarah K.

AU - Pereira-Leal, Jose B.

AU - Nilsson, Daniel

AU - Peterson, Jeremy

AU - Salzberg, Steven L.

AU - Shallom, Joshua

AU - Silva, Joana C.

AU - Sundaram, Jaideep

AU - Westenberger, Scott

AU - White, Owen

AU - Melville, Sara E.

AU - Donelson, John E.

AU - Andersson, Björn

AU - Stuart, Kenneth D.

AU - Hall, Neil

PY - 2005/7/15

Y1 - 2005/7/15

N2 - A comparison of gene content and genome architecture of Trypanosoma brucei, Trypanosoma cruzi, and Leishmania major, three related pathogens with different life cycles and disease pathology, revealed a conserved core proteome of about 6200 genes in large syntenic polycistronic gene clusters. Many species-specific genes, especially large surface antigen families, occur at nonsyntenic chromosome-internal and subtelomeric regions. Retroelements, structural RNAs, and gene family expansion are often associated with syntenic discontinuities that-along with gene divergence, acquisition and loss, and rearrangement within the syntenic regions-have shaped the genomes of each parasite. Contrary to recent reports, our analyses reveal no evidence that these species are descended from an ancestor that contained a photosynthetic endosymbiont.

AB - A comparison of gene content and genome architecture of Trypanosoma brucei, Trypanosoma cruzi, and Leishmania major, three related pathogens with different life cycles and disease pathology, revealed a conserved core proteome of about 6200 genes in large syntenic polycistronic gene clusters. Many species-specific genes, especially large surface antigen families, occur at nonsyntenic chromosome-internal and subtelomeric regions. Retroelements, structural RNAs, and gene family expansion are often associated with syntenic discontinuities that-along with gene divergence, acquisition and loss, and rearrangement within the syntenic regions-have shaped the genomes of each parasite. Contrary to recent reports, our analyses reveal no evidence that these species are descended from an ancestor that contained a photosynthetic endosymbiont.

UR - http://www.scopus.com/inward/record.url?scp=22244472295&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=22244472295&partnerID=8YFLogxK

U2 - 10.1126/science.1112181

DO - 10.1126/science.1112181

M3 - Article

C2 - 16020724

AN - SCOPUS:22244472295

SN - 0036-8075

VL - 309

SP - 404-409+435

JO - Science

JF - Science

IS - 5733

ER -

Comparative genomics of trypanosomatid parasitic protozoa

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this